Immune checkpoint inhibitors plus chemotherapy versus chemotherapy alone as first-line therapy for advanced gastric and esophageal cancers: A systematic review and meta-analysis

•First-line immune checkpoint inhibitors (ICIs) plus chemotherapy showed superior effect over chemotherapy alone in terms of overall survival, progression-free survival, objective response rate, and disease control rate in patients suffering from gastric and esophageal cancers.•Significant predictor...

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Bibliographic Details
Published in:International immunopharmacology 2022-12, Vol.113, p.109317-109317, Article 109317
Main Authors: Noori, Maryam, Mahjoubfar, Aref, Azizi, Shadi, Fayyaz, Farimah, Rezaei, Nima
Format: Article
Language:English
Subjects:
Chemotherapy
Esophageal cancer
Gastric cancer
Immune checkpoint inhibitor
Meta-analysis
Systematic review
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Summary:•First-line immune checkpoint inhibitors (ICIs) plus chemotherapy showed superior effect over chemotherapy alone in terms of overall survival, progression-free survival, objective response rate, and disease control rate in patients suffering from gastric and esophageal cancers.•Significant predictors of overall survival benefit in combination therapy versus chemotherapy alone were PDL-1 combined positive score (CPS) ≥ 10 compared to CPS 
ISSN:1567-5769
1878-1705
DOI:10.1016/j.intimp.2022.109317