Positive predictive value of LI-RADS US-3 observations: multivariable analysis of clinical and imaging features

Purpose To determine how clinical and imaging features affect the positive predictive values (PPV) of US-3 observations. Methods In this retrospective study, 10,546 adult patients who were high risk for hepatocellular carcinoma (HCC) from 2017 to 2021 underwent ultrasound screening/surveillance. Of...

Full description

Saved in:
Bibliographic Details
Published in:Abdominal imaging 2023-01, Vol.48 (1), p.271-281
Main Authors: Tse, Justin R., Shen, Luyao, Tiyarattanachai, Thodsawit, Bird, Kristen N., Liang, Tie, Yoon, Luke, Kamaya, Aya
Format: Article
Language:English
Subjects:
Adult
Cancer
Carcinoma, Hepatocellular - diagnostic imaging
Carcinoma, Hepatocellular - pathology
Cirrhosis
Computed tomography
Confidence intervals
Contrast Media
Diagnostic systems
Female
Gastroenterology
Hepatobiliary
Hepatocellular carcinoma
Hepatology
Humans
Imaging
Liver cancer
Liver cirrhosis
Liver Cirrhosis - diagnostic imaging
Liver Neoplasms - diagnostic imaging
Liver Neoplasms - pathology
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Medical imaging
Medicine
Medicine & Public Health
Predictive Value of Tests
Radiology
Retrospective Studies
Risk groups
Sensitivity and Specificity
Statistical analysis
Ultrasonic imaging
Ultrasound
α-Fetoprotein
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose To determine how clinical and imaging features affect the positive predictive values (PPV) of US-3 observations. Methods In this retrospective study, 10,546 adult patients who were high risk for hepatocellular carcinoma (HCC) from 2017 to 2021 underwent ultrasound screening/surveillance. Of these, 225 adult patients (100 women, 125 men)  with an US-3 observation underwent diagnostic characterization with multiphasic CT (93; 41%), MRI (130; 58%), or contrast-enhanced ultrasound (2; 1%). US-3 observations included focal observations ≥ 10 mm in 216 patients and new venous thrombi in 9 patients. PPV with 95% confidence intervals were calculated using diagnostic characterization as the reference standard. Multivariable analysis of clinical and imaging features was performed to determine the strongest associations with cancer. Results Overall PPV for an US-3 observation was 33% (27–39%) for at least intermediate probability of cancer (≥ LR-3) and 15% (10–20%) for at least probable cancer (≥ LR-4). At multivariable analysis, cirrhosis had the strongest effect size for at least probable cancer ( p  
ISSN:2366-0058
2366-004X
2366-0058
DOI:10.1007/s00261-022-03681-4