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Higher sirt1 is associated with a better body composition in master sprinters and untrained peers
Sirt1 is an enzyme involved in several anti-aging pathways. Associations between Sirt1, age, and body fat (BF) were assessed in master sprinters (MS; n = 35 ; 50.25 ±5.93 yr.), untrained young non-athletes (UY; n = 32 ; 23.78 ±3.98 yr.), and untrained middle-aged (UMA; n = 24 ; 47.29 ±8.04 yr.)....
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| Published in: | European journal of sport science 2023-07, Vol.23 (7), p.1251-1258 |
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| container_end_page | 1258 |
| container_issue | 7 |
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| container_title | European journal of sport science |
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| creator | Leite, Patrício Lopes de Araújo Maciel, Larissa Alves Santos, Patrick Anderson Barbosa, Lucas Pinheiro Gutierrez, Sara Duarte Corrêa, Hugo de Luca Deus, Lysleine Alves de Araújo, Marcia Cristina Aguiar, Samuel da Silva Rosa, Thiago dos Santos Lewis, John E. Simões, Herbert Gustavo |
| description | Sirt1 is an enzyme involved in several anti-aging pathways. Associations between Sirt1, age, and body fat (BF) were assessed in master sprinters (MS; n =
35
; 50.25 ±5.93 yr.), untrained young non-athletes (UY; n =
32
; 23.78 ±3.98 yr.), and untrained middle-aged (UMA; n =
24
; 47.29 ±8.04 yr.). BF was assessed using a skinfold protocol, and Sirt1 was measured in plasma by using commercial kits. Sirt1 of MS (17.18 ±4.77 ng/mL) was higher than UMA (6.36 ±2.29 ng/mL; p |
| doi_str_mv | 10.1080/17461391.2022.2138556 |
| format | article |
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35
; 50.25 ±5.93 yr.), untrained young non-athletes (UY; n =
32
; 23.78 ±3.98 yr.), and untrained middle-aged (UMA; n =
24
; 47.29 ±8.04 yr.). BF was assessed using a skinfold protocol, and Sirt1 was measured in plasma by using commercial kits. Sirt1 of MS (17.18 ±4.77 ng/mL) was higher than UMA (6.36 ±2.29 ng/mL; p<0.0001) and did not differ from UY (20.26 ±6.20 ng/mL). Relative BF of MS was lower than UMA (12.71 ±4.07% vs. 22.13 ±4.18%; p<0.0001). Sirt1 was negatively correlated with chronological age (r = −0.735; p<0.0001) when combining UY and UMA in the analysis. However, when Sirt1 of MS and UY was analyzed together, no significant relationship between Sirt1 and chronological age was observed (r = −0.243; p = 0.083). Sirt1 correlated inversely with BF (r = −0.743; p<0.0001) for UY and UMA. Stepwise multiple regression revealed that being either a young or master athlete and body adiposity are possible predictors of Sirt1 levels. MS and UY were associated with higher levels of Sirt1, while UMA and increased BF were associated with lower levels of this enzyme. The relationships among Sirt1, BF, and chronological age of young and middle-aged non-athletes were not statistically significant when the middle-aged participants were MS. These findings suggest possible links between Sirt1 and body composition, which may play roles in the rate of biological aging.
Highlights
Lower levels of Sirt1 are associated with higher body fat.
Master athlete lifestyle seems to promote higher Sirt1 Levels.</description><identifier>ISSN: 1746-1391</identifier><identifier>ISSN: 1536-7290</identifier><identifier>EISSN: 1536-7290</identifier><identifier>DOI: 10.1080/17461391.2022.2138556</identifier><identifier>PMID: 36259465</identifier><language>eng</language><publisher>England: Routledge</publisher><subject>Adiposity ; ageing ; Aging ; Body Composition ; exercise ; health ; Humans ; Middle Aged ; Obesity ; Sirtuin 1 - metabolism</subject><ispartof>European journal of sport science, 2023-07, Vol.23 (7), p.1251-1258</ispartof><rights>2022 European College of Sport Science 2022</rights><rights>European College of Sport Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4210-2082bce34912f9fee54f9e5b640050e256a83983777133dc29c933fe457632a63</citedby><cites>FETCH-LOGICAL-c4210-2082bce34912f9fee54f9e5b640050e256a83983777133dc29c933fe457632a63</cites><orcidid>0000-0003-0418-0945 ; 0000-0002-2378-4026 ; 0000-0001-9970-5868 ; 0000-0002-3080-9391 ; 0000-0002-8490-7368 ; 0000-0002-9057-4096 ; 0000-0001-5594-3717</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36259465$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leite, Patrício Lopes de Araújo</creatorcontrib><creatorcontrib>Maciel, Larissa Alves</creatorcontrib><creatorcontrib>Santos, Patrick Anderson</creatorcontrib><creatorcontrib>Barbosa, Lucas Pinheiro</creatorcontrib><creatorcontrib>Gutierrez, Sara Duarte</creatorcontrib><creatorcontrib>Corrêa, Hugo de Luca</creatorcontrib><creatorcontrib>Deus, Lysleine Alves de</creatorcontrib><creatorcontrib>Araújo, Marcia Cristina</creatorcontrib><creatorcontrib>Aguiar, Samuel da Silva</creatorcontrib><creatorcontrib>Rosa, Thiago dos Santos</creatorcontrib><creatorcontrib>Lewis, John E.</creatorcontrib><creatorcontrib>Simões, Herbert Gustavo</creatorcontrib><title>Higher sirt1 is associated with a better body composition in master sprinters and untrained peers</title><title>European journal of sport science</title><addtitle>Eur J Sport Sci</addtitle><description>Sirt1 is an enzyme involved in several anti-aging pathways. Associations between Sirt1, age, and body fat (BF) were assessed in master sprinters (MS; n =
35
; 50.25 ±5.93 yr.), untrained young non-athletes (UY; n =
32
; 23.78 ±3.98 yr.), and untrained middle-aged (UMA; n =
24
; 47.29 ±8.04 yr.). BF was assessed using a skinfold protocol, and Sirt1 was measured in plasma by using commercial kits. Sirt1 of MS (17.18 ±4.77 ng/mL) was higher than UMA (6.36 ±2.29 ng/mL; p<0.0001) and did not differ from UY (20.26 ±6.20 ng/mL). Relative BF of MS was lower than UMA (12.71 ±4.07% vs. 22.13 ±4.18%; p<0.0001). Sirt1 was negatively correlated with chronological age (r = −0.735; p<0.0001) when combining UY and UMA in the analysis. However, when Sirt1 of MS and UY was analyzed together, no significant relationship between Sirt1 and chronological age was observed (r = −0.243; p = 0.083). Sirt1 correlated inversely with BF (r = −0.743; p<0.0001) for UY and UMA. Stepwise multiple regression revealed that being either a young or master athlete and body adiposity are possible predictors of Sirt1 levels. MS and UY were associated with higher levels of Sirt1, while UMA and increased BF were associated with lower levels of this enzyme. The relationships among Sirt1, BF, and chronological age of young and middle-aged non-athletes were not statistically significant when the middle-aged participants were MS. These findings suggest possible links between Sirt1 and body composition, which may play roles in the rate of biological aging.
Highlights
Lower levels of Sirt1 are associated with higher body fat.
Master athlete lifestyle seems to promote higher Sirt1 Levels.</description><subject>Adiposity</subject><subject>ageing</subject><subject>Aging</subject><subject>Body Composition</subject><subject>exercise</subject><subject>health</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Sirtuin 1 - metabolism</subject><issn>1746-1391</issn><issn>1536-7290</issn><issn>1536-7290</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNqNkE1vGyEQhlGVqvnqT2jEMZd1-VhguURtrKRpFamHJGfEsrMJ0S64gGX53wfLTo9VT4yGZ96BB6EvlCwo6chXqlpJuaYLRhhbMMo7IeQHdEIFl41imhzVujLNDjpGpzm_ElIbrPuEjrlkQrdSnCB7559fIOHsU6HYZ2xzjs7bAgPe-PKCLe6hlEr0cdhiF-dVzL74GLAPeLZ5d5VXyYda1Okw4HUoyfpQA1ZQe-fo42inDJ8P5xl6ur15XN41979__Fx-v29cyyhpGOlY74C3mrJRjwCiHTWIXraECAJMSNtx3XGlFOV8cEw7zfkIrVCSMyv5Gbrc565S_LOGXMzss4NpsgHiOhumWM1SincVFXvUpZhzgtHUD8w2bQ0lZmfXvNs1O7vmYLfOXRxWrPsZhr9T7zorcLUHNn6C7f-lmptfD8vrW1IFkBrwbR_gwxjTbDcxTYMpdjvFNCYbnM-G__uRbxSQmhw</recordid><startdate>202307</startdate><enddate>202307</enddate><creator>Leite, Patrício Lopes de Araújo</creator><creator>Maciel, Larissa Alves</creator><creator>Santos, Patrick Anderson</creator><creator>Barbosa, Lucas Pinheiro</creator><creator>Gutierrez, Sara Duarte</creator><creator>Corrêa, Hugo de Luca</creator><creator>Deus, Lysleine Alves de</creator><creator>Araújo, Marcia Cristina</creator><creator>Aguiar, Samuel da Silva</creator><creator>Rosa, Thiago dos Santos</creator><creator>Lewis, John E.</creator><creator>Simões, Herbert Gustavo</creator><general>Routledge</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0418-0945</orcidid><orcidid>https://orcid.org/0000-0002-2378-4026</orcidid><orcidid>https://orcid.org/0000-0001-9970-5868</orcidid><orcidid>https://orcid.org/0000-0002-3080-9391</orcidid><orcidid>https://orcid.org/0000-0002-8490-7368</orcidid><orcidid>https://orcid.org/0000-0002-9057-4096</orcidid><orcidid>https://orcid.org/0000-0001-5594-3717</orcidid></search><sort><creationdate>202307</creationdate><title>Higher sirt1 is associated with a better body composition in master sprinters and untrained peers</title><author>Leite, Patrício Lopes de Araújo ; Maciel, Larissa Alves ; Santos, Patrick Anderson ; Barbosa, Lucas Pinheiro ; Gutierrez, Sara Duarte ; Corrêa, Hugo de Luca ; Deus, Lysleine Alves de ; Araújo, Marcia Cristina ; Aguiar, Samuel da Silva ; Rosa, Thiago dos Santos ; Lewis, John E. ; Simões, Herbert Gustavo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4210-2082bce34912f9fee54f9e5b640050e256a83983777133dc29c933fe457632a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adiposity</topic><topic>ageing</topic><topic>Aging</topic><topic>Body Composition</topic><topic>exercise</topic><topic>health</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Sirtuin 1 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leite, Patrício Lopes de Araújo</creatorcontrib><creatorcontrib>Maciel, Larissa Alves</creatorcontrib><creatorcontrib>Santos, Patrick Anderson</creatorcontrib><creatorcontrib>Barbosa, Lucas Pinheiro</creatorcontrib><creatorcontrib>Gutierrez, Sara Duarte</creatorcontrib><creatorcontrib>Corrêa, Hugo de Luca</creatorcontrib><creatorcontrib>Deus, Lysleine Alves de</creatorcontrib><creatorcontrib>Araújo, Marcia Cristina</creatorcontrib><creatorcontrib>Aguiar, Samuel da Silva</creatorcontrib><creatorcontrib>Rosa, Thiago dos Santos</creatorcontrib><creatorcontrib>Lewis, John E.</creatorcontrib><creatorcontrib>Simões, Herbert Gustavo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of sport science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leite, Patrício Lopes de Araújo</au><au>Maciel, Larissa Alves</au><au>Santos, Patrick Anderson</au><au>Barbosa, Lucas Pinheiro</au><au>Gutierrez, Sara Duarte</au><au>Corrêa, Hugo de Luca</au><au>Deus, Lysleine Alves de</au><au>Araújo, Marcia Cristina</au><au>Aguiar, Samuel da Silva</au><au>Rosa, Thiago dos Santos</au><au>Lewis, John E.</au><au>Simões, Herbert Gustavo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Higher sirt1 is associated with a better body composition in master sprinters and untrained peers</atitle><jtitle>European journal of sport science</jtitle><addtitle>Eur J Sport Sci</addtitle><date>2023-07</date><risdate>2023</risdate><volume>23</volume><issue>7</issue><spage>1251</spage><epage>1258</epage><pages>1251-1258</pages><issn>1746-1391</issn><issn>1536-7290</issn><eissn>1536-7290</eissn><abstract>Sirt1 is an enzyme involved in several anti-aging pathways. Associations between Sirt1, age, and body fat (BF) were assessed in master sprinters (MS; n =
35
; 50.25 ±5.93 yr.), untrained young non-athletes (UY; n =
32
; 23.78 ±3.98 yr.), and untrained middle-aged (UMA; n =
24
; 47.29 ±8.04 yr.). BF was assessed using a skinfold protocol, and Sirt1 was measured in plasma by using commercial kits. Sirt1 of MS (17.18 ±4.77 ng/mL) was higher than UMA (6.36 ±2.29 ng/mL; p<0.0001) and did not differ from UY (20.26 ±6.20 ng/mL). Relative BF of MS was lower than UMA (12.71 ±4.07% vs. 22.13 ±4.18%; p<0.0001). Sirt1 was negatively correlated with chronological age (r = −0.735; p<0.0001) when combining UY and UMA in the analysis. However, when Sirt1 of MS and UY was analyzed together, no significant relationship between Sirt1 and chronological age was observed (r = −0.243; p = 0.083). Sirt1 correlated inversely with BF (r = −0.743; p<0.0001) for UY and UMA. Stepwise multiple regression revealed that being either a young or master athlete and body adiposity are possible predictors of Sirt1 levels. MS and UY were associated with higher levels of Sirt1, while UMA and increased BF were associated with lower levels of this enzyme. The relationships among Sirt1, BF, and chronological age of young and middle-aged non-athletes were not statistically significant when the middle-aged participants were MS. These findings suggest possible links between Sirt1 and body composition, which may play roles in the rate of biological aging.
Highlights
Lower levels of Sirt1 are associated with higher body fat.
Master athlete lifestyle seems to promote higher Sirt1 Levels.</abstract><cop>England</cop><pub>Routledge</pub><pmid>36259465</pmid><doi>10.1080/17461391.2022.2138556</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-0418-0945</orcidid><orcidid>https://orcid.org/0000-0002-2378-4026</orcidid><orcidid>https://orcid.org/0000-0001-9970-5868</orcidid><orcidid>https://orcid.org/0000-0002-3080-9391</orcidid><orcidid>https://orcid.org/0000-0002-8490-7368</orcidid><orcidid>https://orcid.org/0000-0002-9057-4096</orcidid><orcidid>https://orcid.org/0000-0001-5594-3717</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1746-1391 |
| ispartof | European journal of sport science, 2023-07, Vol.23 (7), p.1251-1258 |
| issn | 1746-1391 1536-7290 1536-7290 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2726407738 |
| source | EBSCOhost SPORTDiscus - Ebooks |
| subjects | Adiposity ageing Aging Body Composition exercise health Humans Middle Aged Obesity Sirtuin 1 - metabolism |
| title | Higher sirt1 is associated with a better body composition in master sprinters and untrained peers |
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