Aβ Deposits in the Neocortex of Adult and Infant Hypoxic Brains, Including in Cases of COVID-19

Abstract The brain of a 58-year-old woman was included as a civilian control in an ongoing autopsy study of military traumatic brain injury (TBI). The woman died due to a polysubstance drug overdose, with Coronavirus Disease 2019 (COVID-19) serving as a contributing factor. Immunohistochemical stain...

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Bibliographic Details
Published in:Journal of neuropathology and experimental neurology 2022-11, Vol.81 (12), p.988-995
Main Authors: Priemer, David S, Rhodes, Charles Harker, Karlovich, Esma, Perl, Daniel P, Goldman, James E
Format: Article
Language:English
Subjects:
Adult
Alzheimer Disease - pathology
Amyloid beta-Peptides - metabolism
Brain - pathology
Brain Injuries, Traumatic - pathology
Coronaviruses
COVID-19
COVID-19 - complications
Drug overdose
Female
Humans
Hypoxia
Hypoxia - pathology
Middle Aged
Neocortex - pathology
Traumatic brain injury
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Summary:Abstract The brain of a 58-year-old woman was included as a civilian control in an ongoing autopsy study of military traumatic brain injury (TBI). The woman died due to a polysubstance drug overdose, with Coronavirus Disease 2019 (COVID-19) serving as a contributing factor. Immunohistochemical stains for β-amyloid (Aβ), routinely performed for the TBI study, revealed numerous, unusual neocortical Aβ deposits. We investigated the autopsied brains of 10 additional young patients (
ISSN:0022-3069
1554-6578
DOI:10.1093/jnen/nlac095