Effects of electroacupuncture on liver function in mice with chronic alcoholic liver injury: visual display by in vivo fluorescence imaging

Objective: Acupuncture can improve the symptoms of alcohol-induced bodily injury and has been accepted by the World Health Organization. In this study, in vivo fluorescence imaging (IVFI) was applied to display and evaluate the effect of electroacupuncture (EA) on liver function (LF) in mice with ch...

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Bibliographic Details
Published in:Acupuncture in medicine : journal of the British Medical Acupuncture Society 2023-08, Vol.41 (4), p.215-223
Main Authors: Song, Xiao-jing, Wang, Shu-you, Jia, Shu-yong, Wang, Guang-jun, Zhang, Wei-bo
Format: Article
Language:English
Subjects:
Acupuncture Points
Animals
Electroacupuncture
Liver
Liver - diagnostic imaging
Liver - metabolism
Liver cirrhosis
Medical imaging
Mice
Optical Imaging
Rodents
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Summary:Objective: Acupuncture can improve the symptoms of alcohol-induced bodily injury and has been accepted by the World Health Organization. In this study, in vivo fluorescence imaging (IVFI) was applied to display and evaluate the effect of electroacupuncture (EA) on liver function (LF) in mice with chronic alcoholic liver injury (cALI). Methods: IVFI of the Cy5.5-galactosylated polylysine (Cy5.5-GP) probe targeting the liver asialoglycoprotein receptor (ASGPR) and liver indocyanine green (ICG) clearance was performed to visually evaluate the effect of EA at ST36 and BL18 on liver reserve function and hepatic metabolism in mice with cALI. In addition, changes in ASGPR expression, serum indexes of LF, and hepatic morphology were observed. Results: After EA at ST36 and BL18, the ASGPR-targeted fluorescence signals (FS) in the liver increased significantly in cALI mice (p 
ISSN:0964-5284
1759-9873
DOI:10.1177/09645284221125248