Implications of computed tomography reconstruction algorithms on coronary atheroma quantification: Comparison with intravascular ultrasound

Advances in coronary computed tomography angiography (CCTA) reconstruction algorithms are expected to enhance the accuracy of CCTA plaque quantification. We aim to evaluate different CCTA reconstruction approaches in assessing vessel characteristics in coronary atheroma using intravascular ultrasoun...

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Bibliographic Details
Published in:Journal of cardiovascular computed tomography 2023-01, Vol.17 (1), p.43-51
Main Authors: Ramasamy, Anantharaman, Hamid A Khan, Ameer, Cooper, Jackie, Simon, Judit, Maurovich-Horvat, Pal, Bajaj, Retesh, Kitslaar, Pieter, Amersey, Rajiv, Jain, Ajay, Deaner, Andrew, Reiber, Johan HC, Moon, James C., Dijkstra, Jouke, Serruys, Patrick W., Mathur, Anthony, Baumbach, Andreas, Torii, Ryo, Pugliese, Francesca, Bourantas, Christos V.
Format: Article
Language:English
Subjects:
Algorithms
Computed Tomography Angiography - methods
Coronary Angiography - methods
Coronary Artery Disease
Coronary computed tomography angiography
Coronary plaque quantification
Coronary Vessels - diagnostic imaging
Humans
Intravascular imaging
Iterative reconstruction
Plaque, Atherosclerotic
Predictive Value of Tests
Tomography, X-Ray Computed - methods
Ultrasonography, Interventional - methods
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Summary:Advances in coronary computed tomography angiography (CCTA) reconstruction algorithms are expected to enhance the accuracy of CCTA plaque quantification. We aim to evaluate different CCTA reconstruction approaches in assessing vessel characteristics in coronary atheroma using intravascular ultrasound (IVUS) as the reference standard. Matched cross-sections (n ​= ​7241) from 50 vessels in 15 participants with chronic coronary syndrome who prospectively underwent CCTA and 3-vessel near-infrared spectroscopy-IVUS were included. Twelve CCTA datasets per patient were reconstructed using two different kernels, two slice thicknesses (0.75 ​mm and 0.50 ​mm) and three different strengths of advanced model-based iterative reconstruction (IR) algorithms. Lumen and vessel wall borders were manually annotated in every IVUS and CCTA cross-section which were co-registered using dedicated software. Image quality was sub-optimal in the reconstructions with a sharper kernel, so these were excluded. Intraclass correlation coefficient (ICC) and repeatability coefficient (RC) were used to compare the estimations of the 6 CT reconstruction approaches with those derived by IVUS. Segment-level analysis showed good agreement between CCTA and IVUS for assessing atheroma volume with approach 0.50/5 (slice thickness 0.50 ​mm and highest strength 5 ADMIRE IR) being the best (total atheroma volume ICC: 0.91, RC: 0.67, p ​
ISSN:1934-5925
1876-861X
DOI:10.1016/j.jcct.2022.09.004