Antioxidant, immunomodulatory, and anti-inflammatory effects of Spirulina in disease conditions: a systematic review

The goal of this review was to critically evaluate the research on the effects of Spirulina (SP) supplementation on pathological conditions in the general population, considering its antioxidant, immunomodulatory, and anti-inflammatory properties. On a total of 1621 records screened, eighteen studie...

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Bibliographic Details
Published in:International journal of food sciences and nutrition 2022-11, Vol.73 (8), p.1047-1056
Main Authors: Calella, Patrizia, Di Dio, Mirella, Cerullo, Giuseppe, Di Onofrio, Valeria, Gallé, Francesca, Liguori, Giorgio
Format: Article
Language:English
Subjects:
anti-inflammatory
Anti-inflammatory agents
antioxidant
Antioxidants
clinical implication
Clinical trials
Food science
Immunomodulation
Immunomodulators
immunomodulatory
Infertility
Inflammation
Spirulina
Systematic review
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Summary:The goal of this review was to critically evaluate the research on the effects of Spirulina (SP) supplementation on pathological conditions in the general population, considering its antioxidant, immunomodulatory, and anti-inflammatory properties. On a total of 1621 records screened, eighteen studies published between 2001 and 2020 met the inclusion criteria. Despite variability in research methodology and patient conditions, the findings of these studies generally support the benefits of supplementing diet with SP in subjects with both transmittable and non-transmittable diseases. Improvements were found for all the conditions studied, with the only exception of male infertility. However, the number of clinically controlled trials examining the effects of SP on specific health conditions is still very low, and some studies show medium quality. Further research in this field is needed to confirm the possible clinical role of Spirulina supplementation in parallel with medical therapies.
ISSN:0963-7486
1465-3478
DOI:10.1080/09637486.2022.2137785