H3N8 subtype avian influenza virus originated from wild birds exhibited dual receptor-binding profiles

•Three H3N8 subtype low pathogenic avian influenza viruses were isolated from wild birds in China during the ordinary surveillance.•The H3N8 from wild birds in the study clustered with two emerged human H3N8 viruses in 2022 in the same Eurasian avian lineage.•The H3N8 from wild birds in the study pr...

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Bibliographic Details
Published in:The Journal of infection 2023-02, Vol.86 (2), p.e36-e39
Main Authors: Tian, Jingman, Li, Minghui, Li, Yulei, Bai, Xiaoli, Song, Xingdong, Zhao, Zhiguo, Ge, Shenfeng, Li, Yuehui, Liu, Jianwen, Shi, Jianzhong, Wang, Xiaoliang, Li, Zhixin, Zhou, Haining, Ma, Long, Zeng, Xianying, Tian, Guobin, Guan, Yuntao, Li, Yanbing, Chen, Hualan
Format: Article
Language:English
Subjects:
Animals
Animals, Wild
Birds
China
H3N8
Humans
Influenza A Virus, H3N8 Subtype
Influenza in Birds
Mammals
Mice
Phylogeny
Receptor binding
Virulence
Wild birds
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Summary:•Three H3N8 subtype low pathogenic avian influenza viruses were isolated from wild birds in China during the ordinary surveillance.•The H3N8 from wild birds in the study clustered with two emerged human H3N8 viruses in 2022 in the same Eurasian avian lineage.•The H3N8 from wild birds in the study presented dual receptors preferences.•The H3N8 from wild birds in the study replicated well in mammalian model without prior adaption. We present the phylogeny, receptor binding property, growth in mammal cells and pathogenicity in mammal model of H3N8 viruses, which were isolated from wild birds in China. The human receptor preference and efficient replication in mice without prior adaption highlight that the H3N8 virus possesses the public threat potential.
ISSN:0163-4453
1532-2742
DOI:10.1016/j.jinf.2022.10.023