Sesquiterpenoids and monoterpenoids from the water decoction of Valeriana officinalis L

Nine previously undescribed compounds including three sesquiterpenoids, three iridoids, two monoterpenoids and a furan fatty acid, along with seventeen known ones, were isolated from the water decoction of roots and rhizomes of Valeriana officinalis L. Structure elucidation of the twenty-six compoun...

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Published in:Phytochemistry (Oxford) 2023-01, Vol.205, p.113474-113474, Article 113474
Main Authors: Li, Shi-Wei, Xue, Bian-Xia, Yang, Tian-Tian, Li, Ran, Zhang, Mingjie, Wang, Miao, Zhang, Li-Hua, Zhang, Peng, Zhang, Yi, Wang, Tao, Wang, Shao-Xia, Wu, Hong-Hua
Format: Article
Language:English
Subjects:
Anti-neuroinflammatory activity
Iridoids
Sesquiterpenoids
Valeriana officinalis L
Valerianaceae
Water decoction
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Summary:Nine previously undescribed compounds including three sesquiterpenoids, three iridoids, two monoterpenoids and a furan fatty acid, along with seventeen known ones, were isolated from the water decoction of roots and rhizomes of Valeriana officinalis L. Structure elucidation of the twenty-six compounds were accomplished by analysis of the extensive spectroscopic data, and the absolute configurations of the nine previously undescribed ones were established by NOESY experiment and the electronic circular dichroism (ECD) simulations. Among them, β-patchoulene-8-O-β-D-glucopyranoside, 11-methoxyl-viburtinal, and protocatechuic acid showed anti-neuroinflammatory potentials by significantly inhibiting the secretion of nitric oxide (NO) on BV-2 cells upon LPS stimulation (p 
ISSN:0031-9422
1873-3700
DOI:10.1016/j.phytochem.2022.113474