Co-Catalyzed Dual C5/C8–H Bond Functionalization of Imidazo[1,2-a]pyrazines with Disulfides and Grignard Reagents

An efficient difunctionalization at C5/C8 of imidazo­[1,2-a]­pyrazines has been developed using disulfides and Grignard reagents under cheap cobalt catalysis. This one-pot, two-step, three-component transformation is performed under mild conditions; various Grignard reagents (aryl and alkyl) and dis...

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Bibliographic Details
Published in:Organic letters 2022-11, Vol.24 (43), p.7918-7923
Main Authors: Zhang, Bo, Zhang, Wensheng, Wang, Jiaoli, Wang, Qiuan, Kambe, Nobuaki, Qiu, Renhua
Format: Article
Language:English
Subjects:
Catalysis
Disulfides
Indicators and Reagents
Molecular Structure
Pyrazines - chemistry
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Summary:An efficient difunctionalization at C5/C8 of imidazo­[1,2-a]­pyrazines has been developed using disulfides and Grignard reagents under cheap cobalt catalysis. This one-pot, two-step, three-component transformation is performed under mild conditions; various Grignard reagents (aryl and alkyl) and disulfides are tolerated. Mechanistic studies and control experiments demonstrate this reaction proceeded via an anionic intermediate.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.2c02937