Secondary metabolites of the leaves of Tricalysia atherura N. Hallé (Rubiaceae) and their potential antiplasmodial activity

One monoterpene indole alkaloid, atheruramine (1) bearing an ether bridge linking, one hydrobenzoin derivative, tricalydioloside (2) and two ursane-type triterpenes, atherurosides (A and B) (3 and 4) were isolated from the leaves of Tricalysia atherura, together with eight known compounds. The struc...

Full description

Saved in:
Bibliographic Details
Published in:Natural product research 2023-09, Vol.37 (17), p.2830-2840
Main Authors: Djikam Sime, Gwladys, Mbabi Nyemeck, Norbert, Zintchem, Auguste Abouem A, October, Natasha, Missi, Marius Balemaken, Farooq, Rabia, Khan, Khalid Mohammed, Ngono Bikobo, Dominique Serge, Choudhary, Muhammad Iqbal, Pegnyemb, Dieudonné Emmanuel
Format: Article
Language:English
Subjects:
antiplasmodial
Antiprotozoal agents
atheruramine
Chloroquine
cytotoxic activities
hydrobenzoin derivative
indole alkaloid
Metabolites
pentacyclic triterpenes
Plasmodium falciparum
Rubiaceae
Secondary metabolites
Tricalysia atherura
Triterpenes
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:One monoterpene indole alkaloid, atheruramine (1) bearing an ether bridge linking, one hydrobenzoin derivative, tricalydioloside (2) and two ursane-type triterpenes, atherurosides (A and B) (3 and 4) were isolated from the leaves of Tricalysia atherura, together with eight known compounds. The structures of these new compounds were elucidated on the basis of the results of spectroscopic analysis, and the relative configurations of compounds 1-3 were established by NOE difference. Four of the metabolites were screened in vitro against both chloroquine (CQ)-sensitive (3D7) and -resistant (Dd2) strains of Plasmodium falciparum; they were found to exhibit moderate activity against chloroquine-resistant (Dd2) (IC 50 64.99-92.29 μg/mL). Meanwhile, crude extract possesses high antiplasmodial activity against both 3D7 and Dd2 strains of P. falciparum (IC 50 4.39-7.54 μg/mL) and high selectivity indices values (SI > 10) and was found to be safe.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2022.2137796