Clinical outcomes of off-pump coronary artery bypass graft in patients with diabetes and non-diabetics: A systematic review and meta-analysis

• Published in: Diabetes & metabolic syndrome clinical research & reviews 2022-11, Vol.16 (11), p.102643-102643, Article 102643
• Main Authors: aeen, Fatemeh Behesht, Pakzad, Reza, Tayebi, Zahra, Kashkooli, Razie Iloon, Abdi, Fatemeh
• Format: Article
• Language: English
• Subjects: Clinical outcome; Diabetes; Off-pump CABG
• ISSN: 1871-4021; 1878-0334
• DOI: 10.1016/j.dsx.2022.102643

Diabetes mellitus is a prevalent risk factor for developing coronary artery disease which worsens the clinical outcomes of patients undergoing coronary artery bypass grafting (CABG). This study aimed to determine the clinical outcomes of patients with diabetes and non-diabetic patients who underwent off-pump CABG surgery. Medline, Scopus, Proquest, Embase, Web of Science, and Google scholar were searched until September 10, 2021. The effect sizes including unstandardized mean difference and odds ratio with 95% confidence interval were calculated using “Metan” package. The Cochran's Q-test and I2 statistic were used to assess heterogeneity, a random-effects model was applied to estimate the pooled effect sizes, and meta-regression was used to investigate the factors affecting heterogeneity between studies. 10 studies with 6200 sample sizes were included in the study. In groups with diabetes, Summary odds ratio (SOR) and 95% confidence interval of infection was 2.18 more than non-diabetic groups. Also, odds renal complication was 1.74 more than non-diabetic groups, and the odds cardiovascular complication in groups with diabetes was 1.30 more than non-diabetics. There were no differences in mortality, neurologic, respiratory and surgical complications between groups with diabetes and non-diabetics. Based on meta-regression results, age (Coefficient: 0.942; p = 0.009) had a significant direct relationship and sample size (Coefficient: 0.001; p = 0.009) had an indirect significant relationship with heterogeneity of neurologic outcomes. There was no significant publication bias in our results. Our study revealed that off-pump CABG led to some significant outcomes in patients with diabetes compared to non-diabetics. Renal and infection complications were higher in patients with diabetes but no significant differences were seen in most of other postoperative outcomes between the two groups. •Off pump CABG in comparison to conventional CABG have some minor advantages.•Off pump CABG led to some significant outcomes in patients with diabetes compared to non-diabetics.•Renal and infection complications were higher in patients with diabetes.•Most of postoperative clinical outcomes didn't differ in DM and NDM patients.