Adverse reactions to inactivated COVID-19 vaccination in patients with chronic liver disease: The effect of anxiety

Studies have shown that patients with chronic liver disease are at a higher risk of contracting novel coronavirus pneumonia than healthy individuals, and many guidelines state that patients with chronic liver disease should be prioritized for COVID-19 vaccination, but there are a few studies on its...

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Published in:Human vaccines & immunotherapeutics 2022-11, Vol.18 (6), p.2136435-2136435
Main Authors: Lv, Li, Lin, Xiao-Qing, Chen, Yan, Chen, He-Dan, Zhang, Mei-Xian, Shao, Hui, Tung, Tao-Hsin, Zhu, Jian-Sheng
Format: Article
Language:English
Subjects:
Adverse drug reaction
anxiety
Coronavirus
COVID-19
COVID-19 - prevention & control
COVID-19 Vaccines - adverse effects
Humans
Liver Diseases
Vaccination - adverse effects
Vaccines
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Summary:Studies have shown that patients with chronic liver disease are at a higher risk of contracting novel coronavirus pneumonia than healthy individuals, and many guidelines state that patients with chronic liver disease should be prioritized for COVID-19 vaccination, but there are a few studies on its safety in CLD patients. We aimed to evaluate the safety of the inactivated COVID-19 vaccine in patients with chronic liver disease, and the effect of anxiety on adverse reactions. A questionnaire survey for self-administered post-vaccination adverse reaction monitoring was conducted from June 17, 2021, to August 11, 2021, in patients with chronic liver disease attending a tertiary care hospital in Taizhou, China. We analyzed the data from of a total of 160 participants who scanned the QR code on social media to respond to the questionnaire. The overall incidence of adverse reactions after COVID-19 vaccination in patients with chronic liver disease was 44.4% (71/160), and the most common adverse reaction was local injection site reaction, accounting for 80.3% of adverse reactions (57/71). No serious adverse reactions were reported. Approximately 53.1% of the patients had anxiety about vaccination, and 51.8% of those who felt anxious reported adverse reactions. The safety of COVID-19 vaccination in patients with chronic liver disease is good, and there is a strong association between adverse reactions and vaccine anxiety. Pre-vaccination education for patients with vaccine anxiety and psychological counseling may reduce reports of adverse reactions and improve patients' confidence in the vaccine.
ISSN:2164-5515
2164-554X
DOI:10.1080/21645515.2022.2136435