Lymph Node and Distant Metastases in Phyllodes Tumor of the Breast

A 54-year-old woman who incidentally noticed a “knot” in her left breast subsequently underwent excisional biopsy which yielded a diagnosis of malignant neoplasm with sarcomatous features. Given the broad differential diagnosis and imaging findings, the patient underwent bilateral mastectomy and int...

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Bibliographic Details
Published in:International journal of surgical pathology 2023-08, Vol.31 (5), p.761-764
Main Authors: Naal, Tawfeq, Saker, Siba, Coldren, Daniel
Format: Article
Language:English
Subjects:
Breasts
Case reports
Lymphatic system
Tumors
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Summary:A 54-year-old woman who incidentally noticed a “knot” in her left breast subsequently underwent excisional biopsy which yielded a diagnosis of malignant neoplasm with sarcomatous features. Given the broad differential diagnosis and imaging findings, the patient underwent bilateral mastectomy and intraoperative sentinel lymph node assessment. An 8.5 cm tumor that was further classified as a malignant phyllodes tumor was identified in the left breast, while the frozen section interpretation came back as positive for metastatic disease which resulted in left axillary lymphadenectomy. Two months later the patient progressed to distant metastatic disease and unfortunately passed away within 6 months after her initial diagnosis. Lymph node metastasis in phyllodes tumor is an exceptionally rare event for which patients usually do not undergo intraoperative sentinel lymph node examination; however high clinical suspicion of metastatic disease would be evidence for further investigation.
ISSN:1066-8969
1940-2465
DOI:10.1177/10668969221125791