Maternal Methyl-Enriched Diet Increases Dopaminergic Tone of the Mesolimbic Brain System in Adult Offspring of WAG/Rij Rats

The aim of this study is to find out whether maternal methyl-enriched diet affects the content of monoamines and their metabolites in brain structures of adult WAG/Rij offspring. It has been shown for the first time that maternal methyl-enriched diet (choline, betaine, folic acid, vitamin B12, L-met...

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Bibliographic Details
Published in:Doklady. Biological sciences 2022-10, Vol.506 (1), p.145-149
Main Authors: Sarkisova, K. Yu, Fedosova, E. A., Shatskova, A. B., Narkevich, V. B., Kudrin, V. S.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Diet
Dopamine receptors
Epilepsy
Evolutionary Biology
Folic acid
Life Sciences
Mesolimbic system
Methionine
Monoamines
Plant Sciences
Vitamin B12
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Summary:The aim of this study is to find out whether maternal methyl-enriched diet affects the content of monoamines and their metabolites in brain structures of adult WAG/Rij offspring. It has been shown for the first time that maternal methyl-enriched diet (choline, betaine, folic acid, vitamin B12, L-methionine, zink) during the perinatal period increases dopaminergic tone of the mesolimbic brain system in adult offspring of WAG/Rij rats, which is accompanied by the suppression of the symptoms of genetic absence epilepsy and comorbid depression. Results suggest that maternal methyl-enriched diet during the perinatal period may be served as a new therapeutic strategy to prevent the development of a hypofunction of the mesolimbic dopaminergic brain system and associated genetic absence epilepsy and comorbid depression in offspring.
ISSN:0012-4966
1608-3105
DOI:10.1134/S001249662205012X