Unexpected false-negative result in a traveller’s malaria diagnosis

A 4-year-old traveller returned from Senegal with symptoms compatible with malaria. Plasmodium falciparum HRP-2 antigen detection was negative, whereas panmalarial aldolase was positive. Microscopy confirmed the presence of P. falciparum trophozoites with parasitaemia of 16%. Discarding other causes...

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Bibliographic Details
Published in:Journal of travel medicine 2023-02, Vol.30 (1)
Main Authors: Perez-Ugarte, Arantxa, Rubio Maturana, Carles, Silgado, Aroa, Zarzuela Serrat, Francesc, Goterris, Lidia, Paredes-Carmona, Fernando, Sulleiro, Elena
Format: Article
Language:English
Subjects:
Aldolase
Antigens
Diarrhea
HRP-2 antigen
Humans
Malaria
Malaria, Falciparum - diagnosis
Medical diagnosis
Plasmodium falciparum
Travel
Trophozoites
Vector-borne diseases
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Summary:A 4-year-old traveller returned from Senegal with symptoms compatible with malaria. Plasmodium falciparum HRP-2 antigen detection was negative, whereas panmalarial aldolase was positive. Microscopy confirmed the presence of P. falciparum trophozoites with parasitaemia of 16%. Discarding other causes of false-negative antigen detection, this is a rare case of prozone effect.
ISSN:1195-1982
1708-8305
DOI:10.1093/jtm/taac124