Changes in Serum Trace Element Concentrations Before and After Surgery in Resectable Breast Cancer

Background/Aim: Minerals and trace elements (TEs) play vital roles in normal biological functions and in all cancers. Breast carcinoma is the most commonly occurring cancer in women. The aim of this study was to evaluate changes in TE levels before and after breast cancer surgery and the clinical ut...

Full description

Saved in:
Bibliographic Details
Published in:Anticancer research 2022-11, Vol.42 (11), p.5323-5334
Main Authors: Takahashi, Eriko, Imai, Kazuhiro, Fukuyama, Mayuko, Terata, Kaori, Nanjo, Hiroshi, Ishiyama, Koichi, Hiroshima, Yuko, Yatsuyanagi, Misako, Kudo, Chiaki, Morishita, Aoi, Wakita, Akiyuki, Takashima, Shinogu, Sato, Yusuke, Nomura, Kyoko, Minamiya, Yoshihiro
Format: Article
Language:English
Subjects:
Biomarkers
Biopsy
Boron
Breast cancer
Breast carcinoma
Chromium
Copper
Inductively coupled plasma mass spectrometry
Lymph nodes
Mass spectrometry
Mass spectroscopy
Minerals
Patients
Selenium
Supplements
Surgery
Titanium
Trace elements
Tumors
Vanadium
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background/Aim: Minerals and trace elements (TEs) play vital roles in normal biological functions and in all cancers. Breast carcinoma is the most commonly occurring cancer in women. The aim of this study was to evaluate changes in TE levels before and after breast cancer surgery and the clinical utility and reliability of TE levels assayed using inductively coupled plasma mass spectrometry (ICP-MS). Patients and Methods: Thirteen patients with ductal carcinoma in situ (DCIS) and 34 with invasive ductal carcinoma (IDC) treated with planned surgery were enrolled between August 2017 and February 2019. Blood samples were collected before and the day after resection of the primary tumor. All enrolled patients received mastectomy or quadrantectomy and axillary lymph node dissection/biopsy. Serum TE concentrations were determined using ICP-MS. Results: Changes in boron, titanium, vanadium, chromium, copper, zinc, and selenium levels from before to after surgery differed between IDC and DCIS patients. Boron and copper levels before surgery and changes in titanium, vanadium, and chromium before and after surgery are potential predictors distinguishing DCIS from IDC. Subset analysis showed that chromium is a potential biomarker for luminal subtype, while titanium and chromium are potential biomarkers for pathological staging. Conclusion: Changes in serum TEs before and after surgery may help with diagnosis and staging of breast cancer and in establishing TE supplementation protocols.
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.16039