Experience of double plasma purification in 603 patients from a single center in Shanghai, China

Introduction To summarize the clinical experiences with double plasma purification (DPP). Method Using Plasauto iQ automatic blood purification system, model KM‐9000 for DPP. Results A total of 603 patients with different entity undergoing 811 purification procedures were included in this study. The...

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Bibliographic Details
Published in:Therapeutic apheresis and dialysis 2023-06, Vol.27 (3), p.488-494
Main Authors: Yang, Xiu Hong, Fu, Shun Kun, Jin, Hui Min
Format: Article
Language:English
Subjects:
Acute Disease
acute pancreatitis
ANCA‐associated vasculitis
China
double‐filtration plasma plasmapheresis
Humans
hyperlipidemia
Hyperlipidemias - therapy
Pancreatitis
plasma purification
Plasmapheresis - methods
Triglycerides
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Summary:Introduction To summarize the clinical experiences with double plasma purification (DPP). Method Using Plasauto iQ automatic blood purification system, model KM‐9000 for DPP. Results A total of 603 patients with different entity undergoing 811 purification procedures were included in this study. The most common purification modes were dual filtration plasma plasmapheresis (DFPP). Hyperlipidemia was the lead entity, 423 patients with hyperlipidemia performed DFPP, and two cases of severe acute pancreatitis caused by extremely high triglyceride levels completely recovered after two consecutive DFPP treatments. DFPP combined with immunosuppressants tended to decrease independent HD and reduced HD frequency in 53 patients with antineutrophil cytoplasmic antibody‐associated vasculitis. Two patients developed hypotensive or hypoglycemia episodes, respectively, during purification procedures. Conclusion DPP is rapid for the treatment of patients with severe hyperlipidemia and acute pancreatitis caused by severely high triglyceride levels. For those who are intolerant to statins，DPP provides another treatment choice. DPP process is safe.
ISSN:1744-9979
1744-9987
DOI:10.1111/1744-9987.13946