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Feasibility of 24‐h urine creatinine clearance as a renal function monitoring tool in spinal cord injury patients
Objective Renal dysfunction is a major cause of morbidity in patients with spinal cord injury (SCI). A 24‐h urine creatinine (Cr) clearance (24‐h urine CCr) is cost‐effective and easy to implement compared to renal scintigraphy in the evaluation of renal function. This study aimed to verify the feas...
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Published in: | International journal of urology 2023-01, Vol.30 (1), p.100-106 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites |
Online Access: | Get full text |
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Summary: | Objective
Renal dysfunction is a major cause of morbidity in patients with spinal cord injury (SCI). A 24‐h urine creatinine (Cr) clearance (24‐h urine CCr) is cost‐effective and easy to implement compared to renal scintigraphy in the evaluation of renal function. This study aimed to verify the feasibility of 24‐h urine CCr in the SCI population by assessing the correlation with effective renal plasma flow (ERPF) on renal scintigraphy.
Methods
Data from 245 SCI patients (189 males, mean age: 50.2 years) were used in this retrospective review. Clinical characteristics, 24‐h urine CCr, serum Cr, comorbidities, and body composition analyses were assessed for correlation with laboratory parameters including renal scintigraphy. Strong predictors of ERPF were determined by multivariate linear regression analysis. Areas under receiver‐operating characteristic curves were calculated to evaluate the discriminating power of 24‐h urine CCr to predict ERPF |
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ISSN: | 0919-8172 1442-2042 |
DOI: | 10.1111/iju.15069 |