Secondary Phosphine Sulfide‐Enabled Iridium‐Catalyzed Asymmetric Allylic Substitution

An iridium‐catalyzed asymmetric synthesis of branched allylic phosphine compounds under mild conditions is reported. Products bearing various functional groups can be synthesized with excellent stereoselectivity (up to 99.9 % ee) and regioselectivity. The employment of phosphine sulfides with relati...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2022-12, Vol.61 (52), p.e202213904-n/a
Main Authors: Wu, Zeng‐Hua, Wang, Huai‐Yu, Yang, Huai‐Lan, Wei, Li‐Hua, Hayashi, Tamio, Duan, Wei‐Liang
Format: Article
Language:English
Subjects:
Asymmetric Allylic Substitution
Asymmetric synthesis
Asymmetry
Catalysts
Chemical synthesis
Chiral Allylic Phosphines
Deactivation
Functional groups
Iridium
Metals
Phosphine
Phosphine Sulfide
Phosphines
Regioselectivity
Stereoselectivity
Substitution reactions
Sulfides
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Summary:An iridium‐catalyzed asymmetric synthesis of branched allylic phosphine compounds under mild conditions is reported. Products bearing various functional groups can be synthesized with excellent stereoselectivity (up to 99.9 % ee) and regioselectivity. The employment of phosphine sulfides with relatively low deactivation capacity against metal catalysts is crucial for the success of this reaction. An iridium‐catalyzed asymmetric synthesis of branched allylic phosphine compounds under mild conditions is reported. Products bearing various functional groups can be synthesized with excellent stereoselectivity (up to 99.9 % ee) and regioselectivity. The employment of phosphine sulfides with relatively low deactivation capacity against metal catalysts is crucial for the success of this reaction.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.202213904