Predictors of muscle hypertrophy responsiveness to electrically evoked resistance training after spinal cord injury

The purpose of the study was to identify potential predictors of muscle hypertrophy responsiveness following neuromuscular electrical stimulation resistance training (NMES-RT) in persons with chronic spinal cord injury (SCI). Data for twenty individuals with motor complete SCI who completed twice we...

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Bibliographic Details
Published in:European journal of applied physiology 2023-03, Vol.123 (3), p.479-493
Main Authors: Gorgey, Ashraf S., Goldsmith, Jacob A., Khalil, Refka E., Liu, Xin-hua, Pan, Jiangping, Cardozo, Christopher, Adler, Robert A.
Format: Article
Language:English
Subjects:
AKT protein
Baclofen
Baclofen - metabolism
Biomedical and Life Sciences
Biomedicine
Biopsy
Body composition
Body fat
Body mass index
Clinical trials
Electric Stimulation Therapy - methods
Electrical stimuli
Human Physiology
Humans
Hypertrophy
Hypertrophy - pathology
Insulin receptor substrate 1
Insulin-like growth factor I
Insulin-like growth factor-binding protein 3
Insulin-like growth factors
Knee
Magnetic resonance imaging
Muscle Spasticity
Muscle, Skeletal - physiology
Myostatin
Neuromuscular electrical stimulation
Occupational Medicine/Industrial Medicine
Original Article
Physical training
Proto-Oncogene Proteins c-akt - metabolism
Resistance Training - methods
Retrospective Studies
Spasticity
Spinal cord injuries
Spinal Cord Injuries - metabolism
Sports Medicine
Strength training
TOR protein
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Summary:The purpose of the study was to identify potential predictors of muscle hypertrophy responsiveness following neuromuscular electrical stimulation resistance training (NMES-RT) in persons with chronic spinal cord injury (SCI). Data for twenty individuals with motor complete SCI who completed twice weekly NMES-RT lasting 12–16 weeks as part of their participation in one of two separate clinical trials were pooled and retrospectively analyzed. Magnetic resonance imaging (MRI) was used to measure muscle cross-sectional area (CSA) of the whole thigh and knee extensor muscle before and after NMES-RT. Muscle biopsies and fasting biomarkers were also measured. Following the completion of the respective NMES-RT trials, participants were classified into either high-responders ( n  = 8; muscle CSA > 20%) or low-responders ( n  = 12; muscle CSA 
ISSN:1439-6319
1439-6327
DOI:10.1007/s00421-022-05069-0