Neurovascular decoupling measured with quantitative susceptibility mapping is associated with cognitive decline in patients with type 2 diabetes

Abstract Disturbance of neurovascular coupling (NVC) is suggested to be one potential mechanism in type 2 diabetes mellitus (T2DM) associated mild cognitive impairment (MCI). However, NVC evidence derived from functional magnetic resonance imaging ignores the relationship of neuronal activity with v...

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Published in:Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2023-04, Vol.33 (9), p.5336-5346
Main Authors: Ni, Min-Hua, Li, Ze-Yang, Sun, Qian, Yu, Ying, Yang, Yang, Hu, Bo, Ma, Teng, Xie, Hao, Li, Si-Ning, Tao, Lan-Qiu, Yuan, Ding-Xin, Zhu, Jun-Ling, Yan, Lin-Feng, Cui, Guang-Bin
Format: Article
Language:English
Subjects:
Brain
Cognition - physiology
Cognitive Dysfunction - pathology
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - pathology
Humans
Magnetic Resonance Imaging - methods
Temporal Lobe
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Summary:Abstract Disturbance of neurovascular coupling (NVC) is suggested to be one potential mechanism in type 2 diabetes mellitus (T2DM) associated mild cognitive impairment (MCI). However, NVC evidence derived from functional magnetic resonance imaging ignores the relationship of neuronal activity with vascular injury. Twenty-seven T2DM patients without MCI and thirty healthy controls were prospectively enrolled. Brain regions with changed susceptibility detected by quantitative susceptibility mapping (QSM) were used as seeds for functional connectivity (FC) analysis. NVC coefficients were estimated using combined degree centrality (DC) with susceptibility or cerebral blood flow (CBF). Partial correlations between neuroimaging indicators and cognitive decline were investigated. In T2DM group, higher susceptibility values in right hippocampal gyrus (R.PHG) were found and were negatively correlated with Naming Ability of Montreal Cognitive Assessment. FC increased remarkably between R.PHG and right middle temporal gyrus (R.MTG), right calcarine gyrus (R.CAL). Both NVC coefficients (DC-QSM and DC-CBF) reduced in R.PHG and increased in R.MTG and R.CAL. Both NVC coefficients in R.PHG and R.MTG increased with the improvement of cognitive ability, especially for executive function. These demonstrated that QSM and DC-QSM coefficients can be promising biomarkers for early evaluation of cognitive decline in T2DM patients and help to better understand the mechanism of NVC.
ISSN:1047-3211
1460-2199
DOI:10.1093/cercor/bhac422