Langendorff-Isolated Rat Heart after Acute Experimental Myocardial Infarction

A comparative analysis of functioning of Langendorff-isolated heart from intact rats, sham-operated rats, and rats with a model of myocardial infarction one day after ligation of the left coronary artery was carried out. No significant differences in inotropic and chronotropic functions of the heart...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2022-10, Vol.173 (6), p.719-722
Main Authors: Kuptsova, A. M., Bugrov, R. K., Ziyatdinova, N. I., Zefirov, T. L.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Cardiomyocytes
Cardiovascular disease
Cell Biology
Comparative analysis
Coronary artery
Coronary vessels
Heart
Heart attack
Heart attacks
Internal Medicine
Laboratory animals
Laboratory Medicine
Myocardial infarction
Pathology
Pathophysiology
Rodents
Skin
Type 2 diabetes
Veins & arteries
Ventricle
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Description
Summary:A comparative analysis of functioning of Langendorff-isolated heart from intact rats, sham-operated rats, and rats with a model of myocardial infarction one day after ligation of the left coronary artery was carried out. No significant differences in inotropic and chronotropic functions of the heart were found in the groups of intact and sham-operated animals. In the group of rats with the myocardial infarction model, an increase in HR and a decrease in the maximum contraction and relaxation rates and left-ventricular developed pressure were shown in comparison with the groups of intact and sham-operated animals. At the same time, in the group of sham-operated animals, a decrease in coronary flow and temporal parameters of contraction was observed.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-022-05623-y