Suppression of the Antioxidant System and PI3K/Akt/mTOR Signaling Pathway in Cisplatin-Resistant Cancer Cells by Quercetin

We studied the effect of quercetin on ovarian adenocarcinoma SKOV-3 cell line and isogenic subline SKOV-3/CDDP resistant to the anticancer drug cisplatin. It was found that in resistant cells, quercetin in a concentration of 100 μM that causes a decrease in the cell viability suppressed the expressi...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2022-10, Vol.173 (6), p.760-764
Main Authors: Hasan, A. A. Sh, Kalinina, E. V., Tatarskiy, V. V., Volodina, Yu. L., Petrova, А. S., Novichkova, M. D., Zhdanov, D. D., Shtil, A. A.
Format: Article
Language:English
Subjects:
1-Phosphatidylinositol 3-kinase
Adenocarcinoma
AKT protein
Antioxidants
Antitumor agents
Apoptosis
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer cells
Cell Biology
Cell cycle
Cell viability
Chemotherapy
Cisplatin
Drug resistance
Enzymes
Flavonoids
Free radicals
Gene expression
Genes
Internal Medicine
Kinases
Laboratory Medicine
Ovaries
Pathology
Quercetin
Signal transduction
Software
TOR protein
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Summary:We studied the effect of quercetin on ovarian adenocarcinoma SKOV-3 cell line and isogenic subline SKOV-3/CDDP resistant to the anticancer drug cisplatin. It was found that in resistant cells, quercetin in a concentration of 100 μM that causes a decrease in the cell viability suppressed the expression of genes encoding the key antioxidant enzymes ( SOD2 , CAT , GPX1 , and HO-1 ), transcription factor Nrf2, and kinases of the PI3K/Akt/mTOR signaling pathway. In parental cells, quercetin, on the contrary, increased the expression of these genes. The results confirm the redox-dependent regulation induced by quercetin and its opposite nature in cisplatin-sensitive and cisplatin-resistant cancer cells.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-022-05626-9