On‐Demand Removable Self‐Healing and pH‐Responsive Europium‐Releasing Adhesive Dressing Enables Inflammatory Microenvironment Modulation and Angiogenesis for Diabetic Wound Healing

• Published in: Small (Weinheim an der Bergstrasse, Germany) Germany), 2023-01, Vol.19 (3), p.e2205489-n/a
• Main Authors: Fu, Meimei, Zhao, Yitao, Wang, Yue, Li, Yue, Wu, Min, Liu, Qi, Hou, Zhiguo, Lu, Zhihui, Wu, Keke, Guo, Jinshan
• Format: Article
• Language: English
• Subjects: Adhesives - chemistry; Angiogenesis; Anti-Bacterial Agents - chemistry; Antiinfectives and antibacterials; Bandages; Biocompatibility; Bond strength; Borax; Coordination compounds; Crosslinking; Diabetes; Diabetes Mellitus; diabetic wound healing; Europium; Humans; Hydrogels - chemistry; Hydrogen bonds; Hydrogen-Ion Concentration; Modulation; Nanotechnology; on‐demand removal; Oxidizing agents; pH‐responsive releasing; Tannic acid; tannin; Wound Healing
• ISSN: 1613-6810; 1613-6829
• DOI: 10.1002/smll.202205489

Current diabetic wound treatments remain unsatisfactory due to the lack of a comprehensive strategy that can integrate strong applicability (tissue adhesiveness, shape adaptability, fast self‐healability, and facile dressing change) with the initiation and smooth connection of the cascade wound healing processes. Herein, benefiting from the multifaceted bonding ability of tannic acid to metal ions and various polymers, a family of tannin–europium coordination complex crosslinked citrate‐based mussel‐inspired bioadhesives (TE‐CMBAs) are specially developed for diabetic wound healing. TE‐CMBAs can gel instantly (< 60 s), possess favorable shape‐adaptability, considerable mechanical strengths, high elasticity, considerable wet tissue adhesiveness (≈40 kPa), favorable photothermal antimicrobial activity, excellent anti‐oxidant activity, biocompatibility, and angiogenetic property. The reversible hydrogen bond crosslinking and sensitive metal–phenolic coordination also confers TE‐CMBAs with self‐healability, pH‐responsive europium ion and TA releasing properties and on‐demand removability upon mixing with borax solution, enabling convenient painless dressing change and the smooth connection of inflammatory microenvironment modulation, angiogenesis promotion, and effective extracellular matrix production leveraging the acidic pH condition of diabetic wounds. This adhesive dressing provides a comprehensive regenerative strategy for diabetic wound management and can be extended to other complicated tissue healing scenarios. Utilizing the multifaceted bonding ability of tannin to organic and inorganic substances, a fast self‐healable, anti‐oxidant, photothermal antimicrobial, pH‐responsive europium ions and tannin releasable and on‐demand removable adhesive dressing is developed. The adhesive provides convenient noninvasive wound closure, enables in‐time painless dressing change, and smoothly connects inflammatory microenvironment modulation and angiogenesis promotion for accelerated diabetic wound healing.