Superficial and functional imaging of the tricipital lymphatic pathway: a modern reintroduction

• Published in: Breast cancer research and treatment 2023, Vol.197 (1), p.235-242
• Main Authors: Friedman, Rosie, Bustos, Valeria P., Pardo, Jaime, Tillotson, Elizabeth, Donohoe, Kevin, Chatterjee, Abhishek, Ciucci, José Luis, Singhal, Dhruv
• Format: Article
• Language: English
• Subjects: Axilla; Breast cancer; Breast Neoplasms - diagnostic imaging; Breast Neoplasms - pathology; Breast Neoplasms - surgery; Cadavers; Cancer research; Female; Forearm; Humans; Indocyanine Green; Lymph Node Excision - methods; Lymph nodes; Lymph Nodes - diagnostic imaging; Lymph Nodes - pathology; Lymphatic diseases; Lymphatic drainage; Lymphatic system; Lymphatic Vessels - diagnostic imaging; Lymphatic Vessels - pathology; Lymphedema; Lymphedema - diagnostic imaging; Lymphedema - etiology; Lymphedema - pathology; Lymphography; Medicine; Medicine & Public Health; Oncology; Original Laboratory Investigation; Reintroduction
• ISSN: 0167-6806; 1573-7217
• DOI: 10.1007/s10549-022-06777-z

Purpose The tricipital, or Caplan’s, lymphatic pathway has been previously identified in cadavers and described as a potential compensatory pathway for lymphatic drainage of the upper extremity, as it may drain lymphatic fluid directly to the scapular lymph nodes, avoiding the axillary lymph node groups. The aim of this study was to map the anatomy of the tricipital pathway in vivo in patients without lymphatic disease. Methods A retrospective review was performed to identify patients with unilateral breast cancer undergoing preoperative Indocyanine green (ICG) lymphography prior to axillary lymph node dissection from May 2021 through January 2022. Exclusion criteria were evidence or known history of upper extremity lymphedema or non-linear channels visualized on ICG. Demographic, oncologic, and ICG imaging data were extracted from a Lymphatic Surgery Database. The primary outcome of this study was the presence and absence of the tricipital pathway. The secondary outcome was major anatomical variations among those with a tricipital pathway. Results Thirty patients underwent preoperative ICG lymphography in the study period. The tricipital pathway was visualized in the posterior upper arm in 90% of patients. In 63% of patients, the pathway had a functional connection to the forearm (long bundle variant) and in 27%, the pathway was isolated to the upper arm without a connection to the forearm (short bundle variant). In those with a long bundle, the contribution was predominantly from the posterior ulnar lymphosome. Anatomic destinations of the tricipital pathway included the deltotricipital groove and the medial upper arm channel, which drains to the axilla. Conclusion When present, the tricipital pathway coursed along the posterior upper arm with variability in its connections to the forearm distally, and the torso proximally. Long-term follow-up studies will help determine the significance of these anatomic variations in terms of individual risk of lymphedema after axillary nodal dissection.