Efficacy of Early Intensive Blood Pressure Management After Thrombectomy: Protocol for a Randomized Controlled Clinical Trial (IDENTIFY)

Background The optimal strategy for blood pressure management after thrombectomy remains unknown. The primary objective of The Early Intensive Blood Pressure Management after Endovascular Thrombectomy (IDENTIFY) study is to explore the efficacy and safety of early intensive blood pressure management...

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Bibliographic Details
Published in:Neurocritical care 2023-02, Vol.38 (1), p.196-203
Main Authors: Zhang, Xuening, Hu, Fayun, Hao, Zilong, Ye, Chen, Wan, Jincheng, Lu, Kun, Pan, Ruosu, Wu, Bo
Format: Article
Language:English
Subjects:
Antihypertensive Agents - therapeutic use
Antihypertensives
Blood pressure
Blood Pressure - physiology
Brain Ischemia - complications
Brain Ischemia - surgery
Cardiovascular disease
Clinical outcomes
Clinical trials
Critical Care Medicine
Endovascular Procedures - methods
Hemorrhage
Humans
Intensive
Internal Medicine
Ischemia
Medicine
Medicine & Public Health
Multicenter Studies as Topic
Neurology
Neurosurgery
Patients
Prospective Studies
Quality of Life
Randomized Controlled Trials as Topic
Recruitment
Stroke
Stroke - complications
Stroke - surgery
Take a Closer Look at Trials
Thrombectomy - methods
Tomography
Treatment Outcome
Veins & arteries
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Summary:Background The optimal strategy for blood pressure management after thrombectomy remains unknown. The primary objective of The Early Intensive Blood Pressure Management after Endovascular Thrombectomy (IDENTIFY) study is to explore the efficacy and safety of early intensive blood pressure management strategies after thrombectomy compared with that of standard management. Methods The IDENTIFY study is a prospective, randomized, open-label, assessor-blinded multicenter clinical trial. Patients with acute anterior circulation ischaemic stroke who underwent endovascular thrombectomy within 6 h of stroke onset, achieved successful recanalization, and had two consecutive blood pressure readings > 130 mm Hg during the first 6 h after thrombectomy will be enrolled and centrally randomized into intensive or standard management groups in a 1:1 ratio. Continuous blood pressure monitoring will be initiated at the end of thrombectomy, and patients with high blood pressure during the transfer to the wards will also be enrolled. For patients in the intensive management group, the target blood pressure will be 
ISSN:1541-6933
1556-0961
DOI:10.1007/s12028-022-01618-9