Vade-MECOM: How to peel back the layers of hematopoiesis

A recent study1 demonstrates how hematopoietic stem cells (HSCs) contribute minimally to blood and immune cell production during development and only become active postnatally. The work also reveals how Mecom expression can be used to distinguish rare HSCs from the more abundant progenitors that ari...

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Bibliographic Details
Published in:Cell stem cell 2022-11, Vol.29 (11), p.1512-1514
Main Authors: Ditadi, Andrea, Sankaran, Vijay G.
Format: Article
Language:English
Subjects:
Cell Differentiation
Embryonic Development
Hematopoiesis
Hematopoietic Stem Cells - metabolism
Transcription Factors - metabolism
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Summary:A recent study1 demonstrates how hematopoietic stem cells (HSCs) contribute minimally to blood and immune cell production during development and only become active postnatally. The work also reveals how Mecom expression can be used to distinguish rare HSCs from the more abundant progenitors that arise to maintain embryonic hematopoiesis. A recent study1 demonstrates how hematopoietic stem cells (HSCs) contribute minimally to blood and immune cell production during development and only become active postnatally. The work also reveals how Mecom expression can be used to distinguish rare HSCs from the more abundant progenitors that arise to maintain embryonic hematopoiesis.
ISSN:1934-5909
1875-9777
DOI:10.1016/j.stem.2022.10.007