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The oncological multidimensional prognostic index is a promising decision-making tool: A real-world analysis in older patients with metastatic colorectal cancer

Approximately 50% of colorectal cancers occur in older patients. International societies recommend geriatric tools to optimise treatment of older patients. Comprehensive Geriatric Assessment (CGA) is a multidimensional assessment used to classify patients as fit, vulnerable, or frail. The CGA-based...

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Published in:European journal of cancer (1990) 2022-12, Vol.177, p.112-119
Main Authors: Procaccio, Letizia, Bergamo, Francesca, Gatti, Maura, Chiusole, Benedetta, Tierno, Giuseppina, Bergo, Eleonora, Daniel, Francesca, Nappo, Floriana, Maddalena, Giulia, Rasola, Cosimo, Barsotti, Giulia, De Grandis, Maria C., Piva, Vittoria M., Rizzato, Mario D., Sergi, Giuseppe, Brunello, Antonella, Zagonel, Vittorina, Lonardi, Sara
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Language:English
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Summary:Approximately 50% of colorectal cancers occur in older patients. International societies recommend geriatric tools to optimise treatment of older patients. Comprehensive Geriatric Assessment (CGA) is a multidimensional assessment used to classify patients as fit, vulnerable, or frail. The CGA-based oncological multidimensional prognostic index (onco-MPI) also classifies patients as high-, intermediate-, or low-risk based on tumour characteristics. We investigated the role of CGA and onco-MPI in older patients with metastatic colorectal cancer (mCRC) in a real-world setting. Data for consecutive mCRC patients aged ≥70 years were retrieved from a prospectively maintained database from 2010 to 2020. We analyzed patients' and tumours' characteristics, and the CGA domains. Onco-MPI was calculated by a validated algorithm derived from CGA domains. Pearson's test was used to verify whether onco-MPI scores and chemotherapy administration were correlated. The study included 488 mCRC patients with a mean age of 76.1 years. According to CGA, 52% of patients were fit, 28% vulnerable, and 20% frail. According to onco-MPI, 9% were low, 54% intermediate, and 37% high-risk. The median OS was 22.7 months. The following factors improved OS: 0–1 ECOG PS, low onco-MPI, fit based on CGA, chemotherapy administration, and doublet regimen. Chemotherapy administration significantly correlated with onco-MPI scores, leading to a survival gain regardless of the risk subgroups. First-line regimen had no impact on survival across the CGA and onco-MPI categories. CGA and onco-MPI scores confirmed their prognostic impact in older mCRC patients and may aid in decision-making and subgroup stratification in dedicated trials. •Geriatric assessment in older cancer patients is recommended by current guidelines.•We analysed onco-MPI and comprehensive geriatric assessment in older mCRC patients.•The study demonstrated the prognostic role of onco-MPI and geriatric assessment.•Onco-MPI adds valuable information for proper management of older cancer patients.•Therapy was modulated by onco-MPI leading to survival benefit in all subgroups.
ISSN:0959-8049
1879-0852
DOI:10.1016/j.ejca.2022.09.023