Cerebral Arteriopathies of Childhood – Current Approaches

• Published in: Seminars in pediatric neurology 2022-10, Vol.43, p.101004-101004, Article 101004
• Main Authors: Davila-Williams, Daniel, Barry, Megan, Vargas, Carolina, Vossough, Arastoo, Bernard, Timothy J., Rafay, Mubeen F.
• Format: Article
• Language: English
• ISSN: 1071-9091; 1558-0776
• DOI: 10.1016/j.spen.2022.101004

Up to more than half of previously healthy children presenting with their first arterial ischemic stroke have a cerebral arteriopathy. Cerebral arteriopathies during childhood can be congenital, reflecting abnormal vessel development, or acquired when caused by disruption of vascular homeostasis. Distinguishing different types of cerebral arteriopathies in children can be challenging but of great clinical value as they may dictate different disease and treatment courses, and clinical and radiologic outcomes. Furthermore, children with stroke due to a specific arteriopathy exhibit distinctive features when compared to those with stroke due to other causes or a different type of arteriopathy. These features become crucial in the management of pediatric stroke by choosing appropriate diagnostic and treatment strategies. The objective of this article is to provide the reader with a comprehensive up-to-date review of the classification, symptoms, diagnosis, treatment, and outcome of cerebral arteriopathies in children.