Crosslinking of dermal sheep collagen using hexamethylene diisocyanate

The use of hexamethylene diisocyanate (HMDIC) as a crosslinking agent for dermal sheep collagen (DSC) was studied. Because HMDIC is only slightly water soluble, a surfactant was used to obtain a clear and micellar crosslinking solution and to promote the penetration of HMDIC in the DSC matrix. Using...

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Bibliographic Details
Published in:Journal of materials science. Materials in medicine 1995-07, Vol.6 (7), p.429-434
Main Authors: Olde Damink, L. H. H., Dijkstra, P. J., Van Luyn, M. J. A., Van Wachem, P. B., Nieuwenhuis, P., Feijen, J.
Format: Article
Language:English
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Summary:The use of hexamethylene diisocyanate (HMDIC) as a crosslinking agent for dermal sheep collagen (DSC) was studied. Because HMDIC is only slightly water soluble, a surfactant was used to obtain a clear and micellar crosslinking solution and to promote the penetration of HMDIC in the DSC matrix. Using optimized conditions treatment of non-crosslinked DSC (N-DSC) with HMDIC (H-DSC) increased the shrinkage temperature (T sub(s)) of N-DSC from 56 degree C to 74 degree C for H-DSC. A linear relation between the decrease in free amine group content and the increase in T sub(s) was observed. Crosslinking with HMDIC did not influence the tensile strength of the N-DSC samples but increased the elongation at break from 141% to 163% and decreased the high-strain modulus from 26 MPa to 16 MPa for the H-DSC samples, respectively.
ISSN:0957-4530
1573-4838
DOI:10.1007/BF00120286