Targeted secretion: Myosin V delivers vesicles through formin condensates

Secretory vesicles are often delivered to very specific targets, like pre-synaptic terminals or cell tips, to focus exocytosis. New work suggests that a biomolecular condensate focuses actin filaments that deliver incoming vesicles through the condensate to the plasma membrane. Secretory vesicles ar...

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Bibliographic Details
Published in:Current biology 2022-11, Vol.32 (21), p.R1228-R1231
Main Authors: Jacobs, Katherine C., Gladfelter, Amy S., Lew, Daniel J.
Format: Article
Language:English
Subjects:
Actin Cytoskeleton - metabolism
Actins - metabolism
Exocytosis
Formins
Myosin Type V - metabolism
Secretory Vesicles - metabolism
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Summary:Secretory vesicles are often delivered to very specific targets, like pre-synaptic terminals or cell tips, to focus exocytosis. New work suggests that a biomolecular condensate focuses actin filaments that deliver incoming vesicles through the condensate to the plasma membrane. Secretory vesicles are often delivered to very specific targets, like pre-synaptic terminals or cell tips, to focus exocytosis. New work suggests that a biomolecular condensate focuses actin filaments that deliver incoming vesicles through the condensate to the plasma membrane.
ISSN:0960-9822
1879-0445
DOI:10.1016/j.cub.2022.10.001