Risk Factors for Cerebrovascular Events in Moyamoya Angiopathy Using 4D Flow MRI: A Pilot Study

Background Little is known about internal carotid artery (ICA) hemodynamics in patients with moyamoya angiopathy (MMA) and its role in cerebrovascular events. Purpose To characterize ICA hemodynamics in MMA patients by 4D flow MRI and investigate its relationship with cerebrovascular events. Study T...

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Bibliographic Details
Published in:Journal of magnetic resonance imaging 2023-07, Vol.58 (1), p.61-68
Main Authors: Wang, Maoxue, Yang, Yongbo, Zhang, Wen, Zhou, Fei, Zhang, Xin, Zhang, Jilei, Zhang, Bing
Format: Article
Language:English
Subjects:
4D flow
Angiography
Average velocity
Blood flow
Brain
Carotid arteries
Carotid artery
Cerebral hemispheres
Cerebral infarction
Damage
Diffusion rate
Field strength
Hemodynamics
Hemorrhage
Ischemia
Lesions
Magnetic resonance imaging
Medical imaging
moyamoya angiopathy
Neuroimaging
Risk factors
Shear stress
Statistical analysis
Statistical tests
stroke
Velocity
Wall shear stresses
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Summary:Background Little is known about internal carotid artery (ICA) hemodynamics in patients with moyamoya angiopathy (MMA) and its role in cerebrovascular events. Purpose To characterize ICA hemodynamics in MMA patients by 4D flow MRI and investigate its relationship with cerebrovascular events. Study Type Prospective. Subjects Seventy MMA patients (50 years old ± 9, 30 males). Field Strength/Sequence Time‐resolved three‐directional velocity encoded fast field echo sequence (4D flow) MRI, T1‐weighted fast field echo sequence, T2 weighted turbo spin echo sequence, diffusion weighted echo planar imaging; T2‐weighted fluid‐attenuated inversion recovery turbo spin echo sequence, susceptibility weighted fast field echo sequence, and time‐of‐flight MR angiography fast field echo sequence at 3.0T. Assessment ICA hemodynamics (maximum and average velocity [Vmax, Vavg], average blood flow [Flowavg], and wall shear stress) were analyzed based on 4D flow data. Cerebral infarction, defined as the occurrence of events, in 124 brain hemispheres was determined according to clinical symptoms and conventional brain MR imaging. Statistical Tests The independent‐samples T test was used to evaluate differences in ICA hemodynamics between infarcted and non‐infarcted hemispheres. Binary logistic regression was performed to investigate the relationship between ICA hemodynamics and events. A P value
ISSN:1053-1807
1522-2586
DOI:10.1002/jmri.28522