Clarifying Optimal Sodium InTake In Cardiovasular and Kidney (COSTICK) Diseases: a study protocol for two randomised controlled trials

While low sodium intake (40 years with stable blood pressure, unchanged anti-hypertensive medications, willing to modify diet and provided written informed consent. Participants were excluded for abnormal sodium handling, heart failure, high dose diuretics, immunosuppression, pregnancy/lactation, po...

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Bibliographic Details
Published in:HRB open research 2021, Vol.4, p.14
Main Authors: Smyth, Andrew, Yusuf, Salim, Kerins, Claire, Corcoran, Colette, Dineen, Roisin, Alvarez-Iglesias, Alberto, Ferguson, John, McDermott, Suzanne, Hernon, Orlaith, Ranjan, Ritika, Nolan, Aoife, Griffin, Matthew, O'Shea, Paula, Canavan, Michelle, O'Donnell, Martin
Format: Article
Language:English
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Summary:While low sodium intake (40 years with stable blood pressure, unchanged anti-hypertensive medications, willing to modify diet and provided written informed consent. Participants were excluded for abnormal sodium handling, heart failure, high dose diuretics, immunosuppression, pregnancy/lactation, postural hypotension, cognitive impairment, high or low body mass index (BMI) or inclusion in another trial. STICK participants had estimated glomerular filtration rate (eGFR) 30-60ml/min/1.73m and were excluded for acute kidney Injury, rapidly declining eGFR; known glomerular disease or current use of non-steroidal anti-inflammatory drugs. For COSIP, participants were excluded for known kidney or cardiovascular disease. Participants were randomized to usual care only (healthy eating) or an additional sodium lowering intervention (target
ISSN:2515-4826
2515-4826
DOI:10.12688/hrbopenres.13210.1