What's next for cancer vaccines

Cancer vaccines have been shown clinically to drive tumor-reactive cell activation, proliferation, and effector function. Unfortunately, tumor eradication by treatment with cancer vaccines has been unsuccessful in many patients. Critical steps are under way to improve vaccine efficacy and combine th...

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Bibliographic Details
Published in:Science translational medicine 2022-11, Vol.14 (670), p.eabo4632-eabo4632
Main Authors: Adamik, Juraj, Butterfield, Lisa H
Format: Article
Language:English
Subjects:
Cancer
Cancer vaccines
Cancer Vaccines - therapeutic use
Cell activation
Humans
Immunotherapy
Neoplasms - therapy
Tumors
Vaccine efficacy
Vaccines
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Summary:Cancer vaccines have been shown clinically to drive tumor-reactive cell activation, proliferation, and effector function. Unfortunately, tumor eradication by treatment with cancer vaccines has been unsuccessful in many patients. Critical steps are under way to improve vaccine efficacy and combine them with immunotherapy and standard-of-care treatments.
ISSN:1946-6234
1946-6242
1946-3242
DOI:10.1126/scitranslmed.abo4632