Diverse limbic comorbidities cause limbic and temporal atrophy in lewy body disease

In contrast to Alzheimer's disease (AD)-related pathology, the influence of comorbid limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) or argyrophilic grains (AG) on structural imaging in Lewy body disease (LBD) has seldom been evaluated. This study aimed t...

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Published in:Parkinsonism & related disorders 2022-12, Vol.105, p.52-57
Main Authors: Sakurai, Keita, Kaneda, Daita, Morimoto, Satoru, Uchida, Yuto, Inui, Shohei, Kimura, Yasuyuki, Cai, Chang, Kato, Takashi, Ito, Kengo, Hashizume, Yoshio
Format: Article
Language:English
Subjects:
Aged
Alzheimer Disease - diagnosis
Argyrophilic grain disease
Atrophy - pathology
Brain - pathology
Comorbidity
Humans
Lewy body disease
Lewy Body Disease - complications
Lewy Body Disease - diagnostic imaging
Lewy Body Disease - epidemiology
Limbic-predominant age-related TDP-43 encephalopathy
Neurofibrillary Tangles - pathology
TDP-43 proteinopathy
Voxel-based morphometry
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Summary:In contrast to Alzheimer's disease (AD)-related pathology, the influence of comorbid limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) or argyrophilic grains (AG) on structural imaging in Lewy body disease (LBD) has seldom been evaluated. This study aimed to investigate whether non-AD limbic comorbidities, including LATE-NC and AG, cause cortical atrophy in LBD. Seventeen patients with pathologically confirmed LBD with lower Braak neurofibrillary tangle stage (
ISSN:1353-8020
1873-5126
DOI:10.1016/j.parkreldis.2022.11.001