Programming Non‐Nucleic Acid Molecules into Computational Nucleic Acid Systems

• Published in: Angewandte Chemie International Edition 2023-01, Vol.62 (2), p.e202214698-n/a
• Main Authors: Zhang, Qiu‐Long, Wang, Yang, Wang, Liang‐Liang, Xie, Fan, Wu, Ruo‐Yue, Ma, Xu‐Yang, Li, Han, Liu, Yan, Yao, Shunchun, Xu, Liang
• Format: Article
• Language: English
• Subjects: Circuits; Computation; Computer applications; Computers, Molecular; Dynamic DNA Nanotechnology; Information Technology; Ligand Integration; Ligands; Logic; Molecular Computation; Nucleic Acid Circuits; Nucleic Acids
• ISSN: 1433-7851; 1521-3773
• DOI: 10.1002/anie.202214698

Nucleic acid (NA) computation has been widely developed in the past years to solve kinds of logic and mathematic issues in both information technologies and biomedical analysis. However, the difficulty to integrate non‐NA molecules limits its power as a universal platform for molecular computation. Here, we report a versatile prototype of hybridized computation integrated with both nucleic acids and non‐NA molecules. Employing the conformationally controlled ligand converters, we demonstrate that non‐NA molecules, including both small molecules and proteins, can be computed as nucleic acid strands to construct the circuitry with increased complexity and scalability, and can be even programmed to solve arithmetical calculations within the computational nucleic acid system. This study opens a new door for molecular computation in which all‐NA circuits can be expanded with integration of various ligands, and meanwhile, ligands can be precisely programmed by the nuclei acid computation. With utilization of conformationally controlled ligand converters, different kinds of non‐nucleic acid molecules, including both small molecules and proteins, can be integrated into nucleic acid computation to construct circuitries with increased complexity and scalability and to even perform algorithmic calculations. This hybridized system establishes a universal platform for molecular computation.