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Higher coronary artery calcium score is associated with increased risk of atrial fibrillation recurrence after catheter ablation
Coronary artery calcium score (CACS) is associated with an increased risk of atrial fibrillation (AF) development, but scarce data are available regarding the impact on AF recurrence. This study aims to assess the impact of CACS on AF recurrence following catheter ablation. Retrospective study of pa...
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| Published in: | Journal of cardiovascular computed tomography 2023-01, Vol.17 (1), p.22-27 |
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| creator | Lopes Fernandes, Sara Ladeiras-Lopes, Ricardo Silva, Mariana Silva, Gualter Cruz, Inês Diaz, Sílvia O. Barros, António S. Saraiva, Francisca Faria, Rita Almeida, João Fonseca, Paulo Gonçalves, Helena Oliveira, Marco Ferreira, Nuno Primo, João Fontes-Carvalho, Ricardo |
| description | Coronary artery calcium score (CACS) is associated with an increased risk of atrial fibrillation (AF) development, but scarce data are available regarding the impact on AF recurrence. This study aims to assess the impact of CACS on AF recurrence following catheter ablation.
Retrospective study of patients with AF undergoing cardiac computed tomography (CCT) before ablation (2017–2019). Patients with coronary artery disease (CAD), significant valvular heart disease and previous catheter ablation were excluded. A cut-off of CACS ≥ 100 was used according to literature.
A total of 311 patients were included (median age 57 [48, 64] years, 65% men and 21% with persistent AF). More than half of the patients had a CACS > 0 (52%) and 18% a CACS ≥ 100. Patients with CACS ≥ 100 were older (64 [59, 69] vs 55 [46, 63] years, p |
| doi_str_mv | 10.1016/j.jcct.2022.10.002 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2736304806</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1934592522002891</els_id><sourcerecordid>2736304806</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-b200f938a386ac77c1954ccdd9cda0fe8080da4a49da799af8dabf681589333f3</originalsourceid><addsrcrecordid>eNp9kLtuFTEQhi0EIiHhBSiQS5o9-LIXW6JBERCkSDRBSmfNjsccH_bsBtsLSsej49UJlFRz--cf-2PslRQ7KWT_9rA7IJadEkrVxk4I9YSdSzP0jenl3dOaW902nVXdGXuR80GIbpDCPGdnuteDGpQ6Z7-v47c9JY5LWmZIDxxSoRoQJozrkec6IB4zh5wXjFDI81-x7HmcMRHkWqaYv_MlcCgpwsRDHFOcJihxmXkiXFOiGYlDKNsdKHvaEhhPkkv2LMCU6eVjvGBfP364vbpubr58-nz1_qZB3fWlGZUQwWoD2vSAw4DSdi2i9xY9iEBGGOGhhdZ6GKyFYDyMoTeyM1ZrHfQFe3PyvU_Lj5VycceYkepDZ1rW7NRQoYjWiL5K1UmKack5UXD3KR4rHCeF28i7g9vIu4381qvk69LrR_91PJL_t_IXdRW8Owmo_vJnpOQyxo2Mj5VScX6J__P_A2PFmCQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2736304806</pqid></control><display><type>article</type><title>Higher coronary artery calcium score is associated with increased risk of atrial fibrillation recurrence after catheter ablation</title><source>ScienceDirect Freedom Collection</source><creator>Lopes Fernandes, Sara ; Ladeiras-Lopes, Ricardo ; Silva, Mariana ; Silva, Gualter ; Cruz, Inês ; Diaz, Sílvia O. ; Barros, António S. ; Saraiva, Francisca ; Faria, Rita ; Almeida, João ; Fonseca, Paulo ; Gonçalves, Helena ; Oliveira, Marco ; Ferreira, Nuno ; Primo, João ; Fontes-Carvalho, Ricardo</creator><creatorcontrib>Lopes Fernandes, Sara ; Ladeiras-Lopes, Ricardo ; Silva, Mariana ; Silva, Gualter ; Cruz, Inês ; Diaz, Sílvia O. ; Barros, António S. ; Saraiva, Francisca ; Faria, Rita ; Almeida, João ; Fonseca, Paulo ; Gonçalves, Helena ; Oliveira, Marco ; Ferreira, Nuno ; Primo, João ; Fontes-Carvalho, Ricardo</creatorcontrib><description>Coronary artery calcium score (CACS) is associated with an increased risk of atrial fibrillation (AF) development, but scarce data are available regarding the impact on AF recurrence. This study aims to assess the impact of CACS on AF recurrence following catheter ablation.
Retrospective study of patients with AF undergoing cardiac computed tomography (CCT) before ablation (2017–2019). Patients with coronary artery disease (CAD), significant valvular heart disease and previous catheter ablation were excluded. A cut-off of CACS ≥ 100 was used according to literature.
A total of 311 patients were included (median age 57 [48, 64] years, 65% men and 21% with persistent AF). More than half of the patients had a CACS > 0 (52%) and 18% a CACS ≥ 100. Patients with CACS ≥ 100 were older (64 [59, 69] vs 55 [46, 63] years, p < 0.001), had more frequently hypertension (68% vs 42%, p < 0.001) and diabetes mellitus (21% vs 10%, p = 0.020). During a median follow-up of 34 months (12–57 months), 98 patients (32%) had AF recurrence. CACS ≥ 100 was associated with increased risk of AF recurrence (unadjusted Cox regression: hazard ratio [HR] 2.0; 95% confidence interval [CI], 1.3–3.1, p = 0.002). After covariate adjustment, CACS ≥ 100 and persistent AF remained independent predictors of AF recurrence (HR, 1.7; 95% CI, 1.0–2.8, p = 0.039 and HR, 2.0; 95% CI, 1.3–3.2, p = 0.004, respectively).
An opportunistic evaluation of CACS could be an important tool to improve clinical care considering that CACS ≥ 100 was independently associated with a 69% increase in the risk of AF recurrence after first catheter ablation.</description><identifier>ISSN: 1934-5925</identifier><identifier>EISSN: 1876-861X</identifier><identifier>DOI: 10.1016/j.jcct.2022.10.002</identifier><identifier>PMID: 36372722</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Atrial Fibrillation ; Atrial fibrillation recurrence ; Calcium ; Cardiac computed tomography ; Catheter ablation ; Catheter Ablation - adverse effects ; Coronary artery calcium score ; Coronary Vessels ; Female ; Humans ; Male ; Middle Aged ; Opportunistic screening ; Predictive Value of Tests ; Recurrence ; Retrospective Studies ; Risk Factors ; Treatment Outcome</subject><ispartof>Journal of cardiovascular computed tomography, 2023-01, Vol.17 (1), p.22-27</ispartof><rights>2022 Society of Cardiovascular Computed Tomography</rights><rights>Copyright © 2022 Society of Cardiovascular Computed Tomography. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-b200f938a386ac77c1954ccdd9cda0fe8080da4a49da799af8dabf681589333f3</citedby><cites>FETCH-LOGICAL-c356t-b200f938a386ac77c1954ccdd9cda0fe8080da4a49da799af8dabf681589333f3</cites><orcidid>0000-0001-8412-9941 ; 0000-0002-5260-5613 ; 0000-0001-9717-6202 ; 0000-0002-5046-8993 ; 0000-0002-9103-5852 ; 0000-0002-9508-6825 ; 0000-0001-9434-7061 ; 0000-0002-0045-8375 ; 0000-0002-7362-3597 ; 0000-0001-7961-9962</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36372722$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lopes Fernandes, Sara</creatorcontrib><creatorcontrib>Ladeiras-Lopes, Ricardo</creatorcontrib><creatorcontrib>Silva, Mariana</creatorcontrib><creatorcontrib>Silva, Gualter</creatorcontrib><creatorcontrib>Cruz, Inês</creatorcontrib><creatorcontrib>Diaz, Sílvia O.</creatorcontrib><creatorcontrib>Barros, António S.</creatorcontrib><creatorcontrib>Saraiva, Francisca</creatorcontrib><creatorcontrib>Faria, Rita</creatorcontrib><creatorcontrib>Almeida, João</creatorcontrib><creatorcontrib>Fonseca, Paulo</creatorcontrib><creatorcontrib>Gonçalves, Helena</creatorcontrib><creatorcontrib>Oliveira, Marco</creatorcontrib><creatorcontrib>Ferreira, Nuno</creatorcontrib><creatorcontrib>Primo, João</creatorcontrib><creatorcontrib>Fontes-Carvalho, Ricardo</creatorcontrib><title>Higher coronary artery calcium score is associated with increased risk of atrial fibrillation recurrence after catheter ablation</title><title>Journal of cardiovascular computed tomography</title><addtitle>J Cardiovasc Comput Tomogr</addtitle><description>Coronary artery calcium score (CACS) is associated with an increased risk of atrial fibrillation (AF) development, but scarce data are available regarding the impact on AF recurrence. This study aims to assess the impact of CACS on AF recurrence following catheter ablation.
Retrospective study of patients with AF undergoing cardiac computed tomography (CCT) before ablation (2017–2019). Patients with coronary artery disease (CAD), significant valvular heart disease and previous catheter ablation were excluded. A cut-off of CACS ≥ 100 was used according to literature.
A total of 311 patients were included (median age 57 [48, 64] years, 65% men and 21% with persistent AF). More than half of the patients had a CACS > 0 (52%) and 18% a CACS ≥ 100. Patients with CACS ≥ 100 were older (64 [59, 69] vs 55 [46, 63] years, p < 0.001), had more frequently hypertension (68% vs 42%, p < 0.001) and diabetes mellitus (21% vs 10%, p = 0.020). During a median follow-up of 34 months (12–57 months), 98 patients (32%) had AF recurrence. CACS ≥ 100 was associated with increased risk of AF recurrence (unadjusted Cox regression: hazard ratio [HR] 2.0; 95% confidence interval [CI], 1.3–3.1, p = 0.002). After covariate adjustment, CACS ≥ 100 and persistent AF remained independent predictors of AF recurrence (HR, 1.7; 95% CI, 1.0–2.8, p = 0.039 and HR, 2.0; 95% CI, 1.3–3.2, p = 0.004, respectively).
An opportunistic evaluation of CACS could be an important tool to improve clinical care considering that CACS ≥ 100 was independently associated with a 69% increase in the risk of AF recurrence after first catheter ablation.</description><subject>Atrial Fibrillation</subject><subject>Atrial fibrillation recurrence</subject><subject>Calcium</subject><subject>Cardiac computed tomography</subject><subject>Catheter ablation</subject><subject>Catheter Ablation - adverse effects</subject><subject>Coronary artery calcium score</subject><subject>Coronary Vessels</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Opportunistic screening</subject><subject>Predictive Value of Tests</subject><subject>Recurrence</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Treatment Outcome</subject><issn>1934-5925</issn><issn>1876-861X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kLtuFTEQhi0EIiHhBSiQS5o9-LIXW6JBERCkSDRBSmfNjsccH_bsBtsLSsej49UJlFRz--cf-2PslRQ7KWT_9rA7IJadEkrVxk4I9YSdSzP0jenl3dOaW902nVXdGXuR80GIbpDCPGdnuteDGpQ6Z7-v47c9JY5LWmZIDxxSoRoQJozrkec6IB4zh5wXjFDI81-x7HmcMRHkWqaYv_MlcCgpwsRDHFOcJihxmXkiXFOiGYlDKNsdKHvaEhhPkkv2LMCU6eVjvGBfP364vbpubr58-nz1_qZB3fWlGZUQwWoD2vSAw4DSdi2i9xY9iEBGGOGhhdZ6GKyFYDyMoTeyM1ZrHfQFe3PyvU_Lj5VycceYkepDZ1rW7NRQoYjWiL5K1UmKack5UXD3KR4rHCeF28i7g9vIu4381qvk69LrR_91PJL_t_IXdRW8Owmo_vJnpOQyxo2Mj5VScX6J__P_A2PFmCQ</recordid><startdate>202301</startdate><enddate>202301</enddate><creator>Lopes Fernandes, Sara</creator><creator>Ladeiras-Lopes, Ricardo</creator><creator>Silva, Mariana</creator><creator>Silva, Gualter</creator><creator>Cruz, Inês</creator><creator>Diaz, Sílvia O.</creator><creator>Barros, António S.</creator><creator>Saraiva, Francisca</creator><creator>Faria, Rita</creator><creator>Almeida, João</creator><creator>Fonseca, Paulo</creator><creator>Gonçalves, Helena</creator><creator>Oliveira, Marco</creator><creator>Ferreira, Nuno</creator><creator>Primo, João</creator><creator>Fontes-Carvalho, Ricardo</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8412-9941</orcidid><orcidid>https://orcid.org/0000-0002-5260-5613</orcidid><orcidid>https://orcid.org/0000-0001-9717-6202</orcidid><orcidid>https://orcid.org/0000-0002-5046-8993</orcidid><orcidid>https://orcid.org/0000-0002-9103-5852</orcidid><orcidid>https://orcid.org/0000-0002-9508-6825</orcidid><orcidid>https://orcid.org/0000-0001-9434-7061</orcidid><orcidid>https://orcid.org/0000-0002-0045-8375</orcidid><orcidid>https://orcid.org/0000-0002-7362-3597</orcidid><orcidid>https://orcid.org/0000-0001-7961-9962</orcidid></search><sort><creationdate>202301</creationdate><title>Higher coronary artery calcium score is associated with increased risk of atrial fibrillation recurrence after catheter ablation</title><author>Lopes Fernandes, Sara ; Ladeiras-Lopes, Ricardo ; Silva, Mariana ; Silva, Gualter ; Cruz, Inês ; Diaz, Sílvia O. ; Barros, António S. ; Saraiva, Francisca ; Faria, Rita ; Almeida, João ; Fonseca, Paulo ; Gonçalves, Helena ; Oliveira, Marco ; Ferreira, Nuno ; Primo, João ; Fontes-Carvalho, Ricardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-b200f938a386ac77c1954ccdd9cda0fe8080da4a49da799af8dabf681589333f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Atrial Fibrillation</topic><topic>Atrial fibrillation recurrence</topic><topic>Calcium</topic><topic>Cardiac computed tomography</topic><topic>Catheter ablation</topic><topic>Catheter Ablation - adverse effects</topic><topic>Coronary artery calcium score</topic><topic>Coronary Vessels</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Opportunistic screening</topic><topic>Predictive Value of Tests</topic><topic>Recurrence</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lopes Fernandes, Sara</creatorcontrib><creatorcontrib>Ladeiras-Lopes, Ricardo</creatorcontrib><creatorcontrib>Silva, Mariana</creatorcontrib><creatorcontrib>Silva, Gualter</creatorcontrib><creatorcontrib>Cruz, Inês</creatorcontrib><creatorcontrib>Diaz, Sílvia O.</creatorcontrib><creatorcontrib>Barros, António S.</creatorcontrib><creatorcontrib>Saraiva, Francisca</creatorcontrib><creatorcontrib>Faria, Rita</creatorcontrib><creatorcontrib>Almeida, João</creatorcontrib><creatorcontrib>Fonseca, Paulo</creatorcontrib><creatorcontrib>Gonçalves, Helena</creatorcontrib><creatorcontrib>Oliveira, Marco</creatorcontrib><creatorcontrib>Ferreira, Nuno</creatorcontrib><creatorcontrib>Primo, João</creatorcontrib><creatorcontrib>Fontes-Carvalho, Ricardo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiovascular computed tomography</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lopes Fernandes, Sara</au><au>Ladeiras-Lopes, Ricardo</au><au>Silva, Mariana</au><au>Silva, Gualter</au><au>Cruz, Inês</au><au>Diaz, Sílvia O.</au><au>Barros, António S.</au><au>Saraiva, Francisca</au><au>Faria, Rita</au><au>Almeida, João</au><au>Fonseca, Paulo</au><au>Gonçalves, Helena</au><au>Oliveira, Marco</au><au>Ferreira, Nuno</au><au>Primo, João</au><au>Fontes-Carvalho, Ricardo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Higher coronary artery calcium score is associated with increased risk of atrial fibrillation recurrence after catheter ablation</atitle><jtitle>Journal of cardiovascular computed tomography</jtitle><addtitle>J Cardiovasc Comput Tomogr</addtitle><date>2023-01</date><risdate>2023</risdate><volume>17</volume><issue>1</issue><spage>22</spage><epage>27</epage><pages>22-27</pages><issn>1934-5925</issn><eissn>1876-861X</eissn><abstract>Coronary artery calcium score (CACS) is associated with an increased risk of atrial fibrillation (AF) development, but scarce data are available regarding the impact on AF recurrence. This study aims to assess the impact of CACS on AF recurrence following catheter ablation.
Retrospective study of patients with AF undergoing cardiac computed tomography (CCT) before ablation (2017–2019). Patients with coronary artery disease (CAD), significant valvular heart disease and previous catheter ablation were excluded. A cut-off of CACS ≥ 100 was used according to literature.
A total of 311 patients were included (median age 57 [48, 64] years, 65% men and 21% with persistent AF). More than half of the patients had a CACS > 0 (52%) and 18% a CACS ≥ 100. Patients with CACS ≥ 100 were older (64 [59, 69] vs 55 [46, 63] years, p < 0.001), had more frequently hypertension (68% vs 42%, p < 0.001) and diabetes mellitus (21% vs 10%, p = 0.020). During a median follow-up of 34 months (12–57 months), 98 patients (32%) had AF recurrence. CACS ≥ 100 was associated with increased risk of AF recurrence (unadjusted Cox regression: hazard ratio [HR] 2.0; 95% confidence interval [CI], 1.3–3.1, p = 0.002). After covariate adjustment, CACS ≥ 100 and persistent AF remained independent predictors of AF recurrence (HR, 1.7; 95% CI, 1.0–2.8, p = 0.039 and HR, 2.0; 95% CI, 1.3–3.2, p = 0.004, respectively).
An opportunistic evaluation of CACS could be an important tool to improve clinical care considering that CACS ≥ 100 was independently associated with a 69% increase in the risk of AF recurrence after first catheter ablation.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>36372722</pmid><doi>10.1016/j.jcct.2022.10.002</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-8412-9941</orcidid><orcidid>https://orcid.org/0000-0002-5260-5613</orcidid><orcidid>https://orcid.org/0000-0001-9717-6202</orcidid><orcidid>https://orcid.org/0000-0002-5046-8993</orcidid><orcidid>https://orcid.org/0000-0002-9103-5852</orcidid><orcidid>https://orcid.org/0000-0002-9508-6825</orcidid><orcidid>https://orcid.org/0000-0001-9434-7061</orcidid><orcidid>https://orcid.org/0000-0002-0045-8375</orcidid><orcidid>https://orcid.org/0000-0002-7362-3597</orcidid><orcidid>https://orcid.org/0000-0001-7961-9962</orcidid></addata></record> |
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| ispartof | Journal of cardiovascular computed tomography, 2023-01, Vol.17 (1), p.22-27 |
| issn | 1934-5925 1876-861X |
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| source | ScienceDirect Freedom Collection |
| subjects | Atrial Fibrillation Atrial fibrillation recurrence Calcium Cardiac computed tomography Catheter ablation Catheter Ablation - adverse effects Coronary artery calcium score Coronary Vessels Female Humans Male Middle Aged Opportunistic screening Predictive Value of Tests Recurrence Retrospective Studies Risk Factors Treatment Outcome |
| title | Higher coronary artery calcium score is associated with increased risk of atrial fibrillation recurrence after catheter ablation |
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