Developmental changes of the fetal and neonatal thyroid gland and functional consequences on the cardiovascular system

Thyroid hormones play an important role in the development and function of the cardiac myocyte. Dysregulation of the thyroid hormone milieu affects the fetal cardiac cells via complex molecular mechanisms, either by altering gene expression or directly by affecting post-translational processes. This...

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Bibliographic Details
Published in:Journal of perinatology 2022-12, Vol.42 (12), p.1576-1586
Main Authors: Kotsopoulou, Ioanna, Vyas, Arpita K., Cory, Melinda J., Chan, Christina S., Jagarapu, Jawahar, Gill, Shamaila, Mudduluru, Manjula, Angelis, Dimitrios
Format: Article
Language:English
Subjects:
631/136/2060/16
692/163/2743/1841
Cardiovascular system
Fetus
Fetuses
Gene expression
Heart
Hormones
Humans
Hypothyroidism
Infant, Newborn
Iodine
Medicine
Medicine & Public Health
Molecular modelling
Myocytes
Neonates
Newborn babies
Pediatric Surgery
Pediatrics
Placenta
Post-translation
Review Article
Thyroid
Thyroid Gland
Thyroid Hormones
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Summary:Thyroid hormones play an important role in the development and function of the cardiac myocyte. Dysregulation of the thyroid hormone milieu affects the fetal cardiac cells via complex molecular mechanisms, either by altering gene expression or directly by affecting post-translational processes. This review offers a comprehensive summary of the effects of thyroid hormones on the developing cardiovascular system and its adaptation. Furthermore, we will highlight the gaps in knowledge and provide suggestions for future research.
ISSN:0743-8346
1476-5543
DOI:10.1038/s41372-022-01559-3