Research progress of immune cells regulating the occurrence and development of osteonecrosis of the femoral head

ObjectiveTo summarize the characteristics of the occurrence and development of osteonecrosis of the femoral head (ONFH), and to review the important regulatory role of immune cells in the progression of ONFH. MethodsThe domestic and foreign literature on the immune regulation of ONFH was reviewed, a...

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Bibliographic Details
Published in:Zhongguo xiu fu chong jian wai ke za zhi 2022-11, Vol.36 (11), p.1428-1433
Main Authors: Cai, Lijun, Wang, Qiuru, Chen, Changjun, Kang, Pengde
Format: Article
Language:Chinese
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Summary:ObjectiveTo summarize the characteristics of the occurrence and development of osteonecrosis of the femoral head (ONFH), and to review the important regulatory role of immune cells in the progression of ONFH. MethodsThe domestic and foreign literature on the immune regulation of ONFH was reviewed, and the relationship between immune cells and the occurrence and development of ONFH was analyzed. ResultsThe ONFH region has a chronic inflammatory reaction and an imbalance between osteoblast and osteoclast, while innate immune cells such as macrophages, neutrophils, dendritic cells, and immune effector cells such as T cells and B cells are closely related to the maintenance of bone homeostasis. ConclusionImmunotherapy targeting the immune cells in the ONFH region and the key factors and proteins in their regulatory pathways may be a feasible method to delay the occurrence, development, and even reverse the pathology of ONFH.
ISSN:1002-1892
DOI:10.7507/1002-1892.202204106