Association of early-onset constipation and diarrhoea with patient outcomes in critically ill ventilated patients: A retrospective observational cohort study

Constipation and diarrhoea are closely related, but few studies have examined them simultaneously. The purpose of this study was to describe patient defecation status after intensive care unit (ICU) admission and determine the association between early-onset constipation and diarrhoea following ICU...

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Bibliographic Details
Published in:Australian critical care 2023-09, Vol.36 (5), p.737-742
Main Authors: Aikawa, Gen, Ouchi, Akira, Sakuramoto, Hideaki, Hoshino, Tetsuya, Enomoto, Yuki, Shimojo, Nobutake, Inoue, Yoshiaki
Format: Article
Language:English
Subjects:
Constipation
Critically ill
Diarrhoea
Gastrointestinal symptoms
Mechanical ventilation
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Summary:Constipation and diarrhoea are closely related, but few studies have examined them simultaneously. The purpose of this study was to describe patient defecation status after intensive care unit (ICU) admission and determine the association between early-onset constipation and diarrhoea following ICU admission with outcomes for critically ill ventilated patients. Patients ventilated for ≥48 h in an ICU were retrospectively investigated, and their defecation status was assessed during the first week after admission. Early-onset constipation and diarrhoea were defined as onset during the first week of ICU admission. The patients were divided into three groups—normal defecation, constipation, and diarrhoea—and multiple comparisons were performed using the Kruskal–Wallis test and the Mann–Whitney U test with Bonferroni adjustment. Additionally, multivariable analysis was performed for mortality and length of stay using the linear and logistic regression models. Of the 85 critically ill ventilated patients, 47 (55%) experienced early-onset constipation and 12 (14%) experienced early-onset diarrhoea. Patients with normal defecation and diarrhoea increased from the 4th and 5th day of ICU admission. Early-onset diarrhoea was significantly associated with the length of ICU stay (B = 7.534, 95% confidence interval: 0.116–14.951). Early-onset constipation and diarrhoea were common in critically ill ventilated patients, and early-onset diarrhoea was associated with the length of ICU stay.
ISSN:1036-7314
1878-1721
DOI:10.1016/j.aucc.2022.10.005