Effect of intrauterine infusion of platelet-rich plasma for women with recurrent implantation failure: a systematic review and meta-analysis

This study evaluated the effect of intrauterine perfusion of autologous platelet-rich plasma (PRP) on pregnancy outcomes in women with recurrent implantation failure (RIF). Key biomedical databases were searched to identify relevant clinical trials and observational studies. Outcomes included clinic...

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Published in:Journal of obstetrics and gynaecology 2023-12, Vol.43 (1), p.2144177-2144177
Main Authors: Deng, Haiyu, Wang, Suqing, Li, Zhijie, Xiao, Lingfei, Ma, Ling
Format: Article
Language:English
Subjects:
Abortion
Abortion, Spontaneous - prevention & control
Administration, Topical
Birth rate
Blood platelets
Blood Transfusion, Autologous - methods
Embryo Implantation - physiology
Female
Humans
Infertility, Female - physiopathology
Infertility, Female - therapy
Live Birth
meta-analysis
Platelet rich plasma
Platelet-Rich Plasma - physiology
Pregnancy
Pregnancy Outcome
Pregnancy Rate
recurrent implantation failure
Systematic review
Uterus - physiopathology
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Summary:This study evaluated the effect of intrauterine perfusion of autologous platelet-rich plasma (PRP) on pregnancy outcomes in women with recurrent implantation failure (RIF). Key biomedical databases were searched to identify relevant clinical trials and observational studies. Outcomes included clinical pregnancy rate, chemical pregnancy rate, implantation rate, live birth rate, and abortion rate. Data was extracted from ten studies (six randomised controlled trials, four cohort studies) involving 1555 patients. Pregnancy outcomes were improved in women treated with PRP compared to controls: clinical pregnancy rate (RR = 1.96, 95% CI [1.67, 2.31], p  
ISSN:0144-3615
1364-6893
DOI:10.1080/01443615.2022.2144177