Anthelmintic resistance of gastrointestinal nematodes in goats: A systematic review and meta-analysis

To review anthelmintic resistance globally in goats including the effect of location, mode of application and dosage on anthelmintic efficacy (assessed using Faecal Egg Count Reduction). Specifically, resistance of the three major classes of anthelmintics – Benzimidazole and Probenzimidazole (BP); A...

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Bibliographic Details
Published in:Veterinary parasitology 2022-12, Vol.312, p.109809-109809, Article 109809
Main Authors: Baudinette, Emily, O’Handley, Ryan, Trengove, Colin
Format: Article
Language:English
Subjects:
Benzimidazole
Drug resistance
Goat
Imidazothiazole
Macrocyclic Lactone
Nematoda – general
Tetrahydropyimidine derivatives
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Summary:To review anthelmintic resistance globally in goats including the effect of location, mode of application and dosage on anthelmintic efficacy (assessed using Faecal Egg Count Reduction). Specifically, resistance of the three major classes of anthelmintics – Benzimidazole and Probenzimidazole (BP); Anti-cholinergics (AC); and Macrocyclic Lactone (ML) was investigated. A PRISMA Framework was followed in order to conduct a thorough assessment of the literature on anthelmintic resistance in goats. A single factor ANOVA test was conducted in Microsoft Excel (2009) to test for the significance of the effect of location, mode of application and dosage on resistance. Three meta-analyses were also conducted in Microsoft Excel (2009) to quantify global resistance levels of the three major anthelmintic classes. Of the 461 publications screened, 105 studies were included in the systematic review and 101 studies were included in the meta-analyses. Anthelmintic class as well as anthelmintic active principle selection in the BP and ML classes did have a significant effect on resistance (p 
ISSN:0304-4017
1873-2550
DOI:10.1016/j.vetpar.2022.109809