Enhanced Topical Co-delivery of Acyclovir and Lidocaine Gel Formulation Across Dermatomed Human Skin

Acyclovir a widely used drug in the treatment of herpes simplex virus (HSV) infections and lidocaine a local anesthetic were combined in a topical gel formulation. The topical gel with Transcutol P (TP) or N-methyl 2-pyrrolidone (NMP) was prepared and tested for in vitro skin permeation across the i...

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Bibliographic Details
Published in:AAPS PharmSciTech 2022-11, Vol.23 (8), p.305-305, Article 305
Main Authors: Annaji, Manjusha, Mita, Nur, Rangari, Shivani, Aldawsari, Mohammed F., Alsaqr, Ahmed, Poudel, Ishwor, Fasina, Oladiran, Babu, R. Jayachandra
Format: Article
Language:English
Subjects:
Active and Passive Permeation Enhancement Strategies for Transdermal Delivery of Bioactive Compounds
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Pharmacology/Toxicology
Pharmacy
Research Article
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Summary:Acyclovir a widely used drug in the treatment of herpes simplex virus (HSV) infections and lidocaine a local anesthetic were combined in a topical gel formulation. The topical gel with Transcutol P (TP) or N-methyl 2-pyrrolidone (NMP) was prepared and tested for in vitro skin permeation across the intact and microneedle-treated human cadaver skin. The topical gels containing 5% each of acyclovir and lidocaine showed optimal pH, spreadability, and 100% drug release. The transdermal flux and skin retention of the gels were significantly higher compared to Generic 5% acyclovir ointment (Zovirax) ( p  
ISSN:1530-9932
1530-9932
DOI:10.1208/s12249-022-02458-8