Multifunctional and multilayer surgical sealant for a better patient safety

[Display omitted] Unmanagable bleeding during combats, road accidents, and intraoperative or external injuries causes a significant rise in mortality. Any biomaterial that can intensify hemostasis, and reduce complications, can reduce mortality and increase the survivability of the subjects. In the...

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Bibliographic Details
Published in:International journal of pharmaceutics 2022-12, Vol.629, p.122411-122411, Article 122411
Main Authors: Chevala, Naga Thirumalesh, Kumar, Lalit, Veetilvalappil, Vimal, Mathew, Aranjani Jesil, Jadhav, Manali, Gandhi, Mayuri, Rao, C. Mallikarjuna
Format: Article
Language:English
Subjects:
Fast disintegrating film
Hemostasis
Multifunctional
Multilayered
Nanoporous
Scaffold
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Summary:[Display omitted] Unmanagable bleeding during combats, road accidents, and intraoperative or external injuries causes a significant rise in mortality. Any biomaterial that can intensify hemostasis, and reduce complications, can reduce mortality and increase the survivability of the subjects. In the present research, we attempted to develop a multifunctional surgical sealant (MfSS) by integrating fast disintegrating film (FDF), nanoporous fibers reinforced composite scaffold (NFRCS), and a flexible silicon layer (FSL). By integrating FDF, NFRCS, and FSL, MfSS was developed. MfSS comprises four layers: two FDFs, one NFRCS, and one FSL. The FSL was surface coated with tissue adhesive glue that retains the MfSS at the application and controls the pressure excited by the blood. The multi-functionality of the MfSS was attained by loading tranexamic acid (TXA) and Epigallocatechin gallate (EGCG) in FDF. The developed FDFs rapidly disintegrate at the application site in the blood pool, help attain high drug concentrations at the application site, and prevent drug washout because of blood. The in vitro characterization studies confirm the possibility of developing the MfSS with four different layers and FDF disintegration in citrated rat blood. The in vivo BCT assay confirms the MfSS activates and intensifies the blood coagulation process in two animal models. The MfSS could regulate the microenvironment, and TXA and EGCG loaded in the FDF could act at the cellular level, resulting in better wound healing in the excision wound model.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2022.122411