Digoxin as an emerging therapy in noncardiac diseases

The cardiac glycoside (CG) digoxin is a generic drug approved for the treatment of heart failure and supraventricular arrhythmias. Over the past few decades, substantial strides have been made toward repurposing digoxin to treat various noncardiac diseases. Here, we evaluate recent insights into bas...

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Bibliographic Details
Published in:Trends in pharmacological sciences (Regular ed.) 2023-04, Vol.44 (4), p.199-203
Main Authors: Dashti, Farzaneh, Jamshed, Fatima, Ouyang, Xinshou, Mehal, Wajahat Z., Banini, Bubu A.
Format: Article
Language:English
Subjects:
alcohol-associated steatohepatitis
cancer
Cardiac Glycosides
digoxin
Digoxin - pharmacology
Digoxin - therapeutic use
drug repurposing
Heart Failure - drug therapy
Humans
Na,K-ATPase
nonalcoholic steatohepatitis
obesity
Ouabain
Sodium-Potassium-Exchanging ATPase - metabolism
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Description
Summary:The cardiac glycoside (CG) digoxin is a generic drug approved for the treatment of heart failure and supraventricular arrhythmias. Over the past few decades, substantial strides have been made toward repurposing digoxin to treat various noncardiac diseases. Here, we evaluate recent insights into basic and clinical work related to noncardiac use of digoxin.
ISSN:0165-6147
1873-3735
DOI:10.1016/j.tips.2022.10.002