Utility of serum autotaxin levels for predicting post hepatectomy liver failure in hepatocellular carcinoma

Background/Purpose This study aimed to evaluate the usefulness of serum autotaxin, a novel liver fibrosis marker, for predicting post hepatectomy liver failure (PHLF) in patients undergoing hepatectomy for hepatocellular carcinoma (HCC). Methods Autotaxin was measured in sera from 269 patients under...

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Published in:Journal of hepato-biliary-pancreatic sciences 2023-06, Vol.30 (6), p.825-833
Main Authors: Uemoto, Yusuke, Taura, Kojiro, Kimura, Yusuke, Yoh, Tomoaki, Nishio, Takahiro, Koyama, Yukinori, Seo, Satoru, Okazaki, Kazuyuki, Nagao, Miki, Igarashi, Koji, Hatano, Etsuro
Format: Article
Language:English
Subjects:
Antibodies
autotaxin
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - surgery
Female
Hepatectomy
Hepatitis
Humans
Liver cancer
Liver Cirrhosis - pathology
Liver Cirrhosis - surgery
Liver Failure
liver fibrosis
Liver Neoplasms - pathology
Liver Neoplasms - surgery
liver resection
Male
Postoperative Complications - surgery
prediction
Retrospective Studies
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Summary:Background/Purpose This study aimed to evaluate the usefulness of serum autotaxin, a novel liver fibrosis marker, for predicting post hepatectomy liver failure (PHLF) in patients undergoing hepatectomy for hepatocellular carcinoma (HCC). Methods Autotaxin was measured in sera from 269 patients undergoing hepatectomy for HCC. Correlations between autotaxin level, liver fibrosis stage (METAVIR F0–F4), and PHLF, as assessed by the International Study Group of Liver Surgery criteria, were analyzed. Results Median autotaxin concentrations correlated significantly with fibrosis stage (F0, 0.93; F1, 0.96; F2, 1.18; F3, 1.40; and F4, 1.47 mg/l; P 
ISSN:1868-6974
1868-6982
DOI:10.1002/jhbp.1278