Pyroptosis in inflammatory bone diseases: Molecular insights and targeting strategies

Inflammatory bone diseases include osteoarthritis (OA) and rheumatoid arthritis (RA), which can cause severe bone damage in a chronic inflammation state, putting tremendous pressure on the patients' families and government agencies regarding medical costs. In addition, the complexity of osteoim...

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Bibliographic Details
Published in:The FASEB journal 2022-12, Vol.36 (12), p.e22670-n/a
Main Authors: Zhang, Ruo‐Nan, Sun, Zhi‐Jun, Zhang, Lu
Format: Article
Language:English
Subjects:
Bone Diseases
caspase
Cell Death
Cytokines - metabolism
gasdermin
Humans
inflammasome
Inflammation - pathology
inflammatory bone diseases
pyroptosis
Pyroptosis - physiology
targeting strategies
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Summary:Inflammatory bone diseases include osteoarthritis (OA) and rheumatoid arthritis (RA), which can cause severe bone damage in a chronic inflammation state, putting tremendous pressure on the patients' families and government agencies regarding medical costs. In addition, the complexity of osteoimmunology makes research on these diseases difficult. Hence, it is urgent to determine the potential mechanisms and find effective drugs to target inflammatory bone diseases to reduce the negative effects of these diseases. Recently, pyroptosis, a gasdermin‐induced necrotic cell death featuring secretion of pro‐inflammatory cytokines and lysis, has become widely known. Based on the effect of pyroptosis on immunity, this process has gradually emerged as a vital component in the etiopathogenesis of inflammatory bone diseases. Herein, we review the characteristics and mechanisms of pyroptosis and then focus on its clinical significance in inflammatory bone diseases. In addition, we summarize the current research progress of drugs targeting pyroptosis to enhance the therapeutic efficacy of inflammatory bone diseases and provide new insights for future directions.
ISSN:0892-6638
1530-6860
DOI:10.1096/fj.202201229R