Dynamic touch induces autonomic changes in preterm infants as measured by changes in heart rate variability

• Published in: Brain research 2023-01, Vol.1799, p.148169-148169, Article 148169
• Main Authors: Manzotti, Andrea, Cerritelli, Francesco, Monzani, Elena, Savioli, Luca, Esteves, Jorge E., Lista, Gianluca, Lombardi, Erica, Rocca, Simona La, Biasi, Pamela, Galli, Matteo, Chiera, Marco, McGlone, Francis P.
• Format: Article
• Language: English
• Subjects: Affective touch; Autonomic nervous system; C-tactile; Female; Heart Rate - physiology; Heart rate variability; Humans; Infant; Infant, Newborn; Infant, Premature; Neonatal intensive care unit; Premature Birth; Preterm infants; Touch - physiology; Touch Perception - physiology
• ISSN: 0006-8993; 1872-6240
• DOI: 10.1016/j.brainres.2022.148169

[Display omitted] •C-tactile afferents respond optimally to dynamic touch.•C-tactile afferents are involved in autonomic and interoceptive regulation.•Several heart rate variability metrics changed in preterm infants after dynamic touch.•Dynamic touch induced a more balanced autonomic nervous system activity.•Static touch induced a strong sympathetic activation. Preterm birth significantly increases the risk of developing various long-term health problems and developmental disabilities. While touch is a crucial component of many perinatal care strategies, the neurobiological underpinnings are rarely considered. C-tactile fibers (CTs) are unmyelinated nerve fibers that are activated by low-force, dynamic touch. Touch directed specifically at CTs activates the posterior insular cortex, consistent with an interoceptive function, and has been shown to reduce heart rate and increase oxygen saturation. The current research compared the effect of five minutes of CT optimal velocity stroking touch versus five minutes of static touch on autonomic markers of preterm infants between 28 and 37 weeks gestational age. CT touch induces a higher increase in heart rate variability metrics related to the parasympathetic system, which persisted for a 5-minute post-touch period. Conversely, there was no such increase in infants receiving static touch. The present findings confirmed that CTs signal the affective quality of nurturing touch, thereby arguing an additional neurobiological substrate for the evident valuable impacts of neonatal tactile interventions and improving the effectiveness of such interventions.