Immunosuppressed patients are at increased risk of local recurrence, metastasis, and disease specific death from cutaneous squamous cell carcinoma

It is well established that immunosuppressed patients are at increased risk for poor outcomes (PO) from cutaneous squamous cell carcinoma (cSCC), including local recurrence (LR), nodal metastasis (NM), distant metastasis (DM), and disease-specific death (DSD). Defining PO risk is challenging but may...

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Bibliographic Details
Published in:Archives of dermatological research 2023-07, Vol.315 (5), p.1429-1433
Main Authors: Lopez, Adriana, Babadzhanov, Marianna, Cheraghlou, Shayan, Canavan, Theresa, Doudican, Nicole, Stevenson, Mary, Carucci, John A.
Format: Article
Language:English
Subjects:
Blood cancer
Carcinoma, Squamous Cell - pathology
Cell death
Dermatology
Humans
Immunocompetence
Immunocompromised Host
Immunosuppression
Medicine
Medicine & Public Health
Metastases
Metastasis
Neoplasm Recurrence, Local - pathology
Neoplasm Staging
Retrospective Studies
Risk factors
Short Report
Skin Neoplasms - pathology
Squamous cell carcinoma
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Summary:It is well established that immunosuppressed patients are at increased risk for poor outcomes (PO) from cutaneous squamous cell carcinoma (cSCC), including local recurrence (LR), nodal metastasis (NM), distant metastasis (DM), and disease-specific death (DSD). Defining PO risk is challenging but may be beneficial in guiding management. We aimed to define PO risk factors and evaluated their importance in immunosuppressed versus immunocompetent patients. We conducted a 4-year single-center retrospective review of patients with cSCC. Patient and tumor characteristics were evaluated in those that experienced PO. Immunosuppressed patients were ~ 11-fold more likely than immunocompetent patients to develop PO (10/85 vs. 15/1332, p  
ISSN:1432-069X
0340-3696
1432-069X
DOI:10.1007/s00403-022-02458-5